Lower embryonic loss rates among twin gestations following assisted reproduction

G. B. La Sala, G. Nucera, A. Gallinelli, A. Nicoli, M. T. Villani, I. Blickstein

Research output: Contribution to journalArticlepeer-review


Purpose: To determine whether maternal age and number of transferred embryos influence early pregnancy losses in twin pregnancies compared to singletons following IVF/ICSI. Methods: We compared the pregnancy loss rates in singleton (n = 549) and twin (n = 252) gestations, stratified by maternal age (≤35 and >35 years) and the number of transferred embryos (1-3 and 4-9). Results: Loss rates of singleton pregnancies were significantly higher than that in twins (OR 3.0, 95% CI 1.9, 4.9), especially among singletons conceived after transfer of 4-9 embryos (OR 5.0, 95% CI 2.2, 11.9). Younger mothers of twins had lower loss rates (OR 0.3, 95% CI 0.1, 0.9). Conclusion: Twins have a significantly reduced spontaneous miscarriage rate compared with singletons following IVF/ICSI. Higher implantation rates per cycle (i.e., development of twins rather than one live embryo) may represent a better capacity of the uterus for early embryonic development.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalJournal of Assisted Reproduction and Genetics
Issue number5
Publication statusPublished - May 2005


  • ICSI
  • IVF
  • Pregnancy loss
  • Singletons
  • Twins

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Developmental Biology
  • Genetics
  • Reproductive Medicine


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