Lower endothelial progenitor cell number, family history of cardiovascular disease and reduced HDL-cholesterol levels are associated with shorter leukocyte telomere length in healthy young adults

A. Dei Cas, V. Spigoni, L. Franzini, M. Preti, D. Ardigò, E. Derlindati, M. Metra, L. D. Monti, P. Dell'Era, L. Gnudi, I. Zavaroni

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims: Leukocyte telomere length (LTL) is a novel marker of cardiovascular (CV) risk. The aim of the study was to investigate the major determinants of LTL in a healthy young population at very low CV risk. Methods and results: LTL was determined in 82 healthy subjects (49M/33F; age37 ± 9yrs), normotensive and not taking any medication with different family history of cardiovascular disease (CVD) (24yes/58no). Fasting blood samples were drawn in all subjects for the determination of lipid profile, high sensitive C-reactive protein, uric acid, Plasminogen Activator Inhibitor-1 (PAI-1), LTL and Endothelial Progenitor Cell (EPC) number. LTL was assessed with a specific real-time PCR reaction in leukocyte DNA samples.LTL resulted inversely correlated with family history of CVD (t = 2.70; p = 0.009), age (r = -0.238; p = 0.032), waist circumference (r = -0.256; p = 0.02), triglycerides (r = -0.218; p = 0.049), PAI-1 (r = -0.288; p = 0.009) and directly correlated with HDL-cholesterol (r = 0.316; p = 0.004) and EPC number (r = 0.358; p = 0.002). At a multivariate analysis, family history of CVD (p = 0.013), EPC count (p = 0.003), and HDL-cholesterol (p = 0.017) were independently associated with LTL (r = 0.62). Conclusion: LTL is independently associated to CV risk factors also in healthy young adults.

Original languageEnglish
Pages (from-to)272-278
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Endothelial progenitor cells
  • Family history of cardiovascular disease
  • HDL-cholesterol
  • Leukocyte telomere length

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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