Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors

M. Schenk, C. Leib-Mösch, I. U. Schenck, M. Jaenicke, S. Indraccolo, H. D. Saeger, G. Dallenbach-Hellweg, R. Hehlmann

Research output: Contribution to journalArticle

Abstract

Inactivation of tumor suppressor genes is thought to be a critical step in tumorigenesis. The DCC (deleted in colorectal carcinoma) gene, located on the long arm of chromosome 18, has been shown to be frequently deleted in colorectal tumors. To investigate the involvement of allelic deletions on chromosome 18q in breast cancer tumorigenesis we analyzed 28 primary breast tumors and 28 colorectal tumors (24 carcinomas, 4 adenomas) with four different polymorphic DNA markers detecting RFLPs on chromosome 18q. In breast cancer we found loss of heterozygosity (LOH) in 4 of 27 (15%) informative cases whereas 15 of 25 (60%) colorectal tumors showed allelic deletions. In all cases of allelic loss the DCC locus or its proximal vicinity (locus SSAV1) were involved. LOH on chromosome 18q occurs both in breast and colorectal cancer, yet the frequency of these deletions in breast tumors is lower than in colorectal tumors. Moreover, in breast cancer these mutations were only detected in large and undifferentiated tumors.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalJournal of Molecular Medicine
Volume74
Issue number3
DOIs
Publication statusPublished - 1996

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Keywords

  • Breast cancer
  • Chromosome 18q
  • Colorectal cancer
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Schenk, M., Leib-Mösch, C., Schenck, I. U., Jaenicke, M., Indraccolo, S., Saeger, H. D., Dallenbach-Hellweg, G., & Hehlmann, R. (1996). Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors. Journal of Molecular Medicine, 74(3), 155-159. https://doi.org/10.1007/BF01575448