TY - JOUR
T1 - Lower motor neuron syndrome in a patient with HER2-positive metastatic breast cancer
T2 - A case report and review of the literature
AU - Diamanti, Luca
AU - Quaquarini, Erica
AU - Berzero, Giulia
AU - Bini, Paola
AU - Gastaldi, Matteo
AU - Franciotta, Diego
AU - Alfonsi, Enrico
AU - Ceroni, Mauro
AU - Frascaroli, Mara
AU - Bernardo, Antonio
AU - Marchioni, Enrico
N1 - Copyright © 2018 Elsevier B.V. All rights reserved.
PY - 2018/9
Y1 - 2018/9
N2 - Paraneoplastic neurological syndromes are very rare and often associated to breast, ovarian and small cells lung cancers. Paraneoplastic motor neuron diseases (MNDs) are even rarer, and frequently described in patients with breast cancer. We presented the first case of patient affected by HER2-positive breast tumor and possible paraneoplastic lower motor neuron disease. In literature, few cases are reported but no one highlights the tumor receptors' profile. Instead, HER2-positive breast cancers are prone to be related to anti-Yo-associated paraneoplastic cerebellar disorders. Anti-onconeural antibodies positivity can be rarely found, confirming that paraneoplastic MND have no specific biomarkers. The presence of CSF oligoclonal bands (OBs) suggests the presence of immune-mediated mechanism, in absence of other possible OBs causes.
AB - Paraneoplastic neurological syndromes are very rare and often associated to breast, ovarian and small cells lung cancers. Paraneoplastic motor neuron diseases (MNDs) are even rarer, and frequently described in patients with breast cancer. We presented the first case of patient affected by HER2-positive breast tumor and possible paraneoplastic lower motor neuron disease. In literature, few cases are reported but no one highlights the tumor receptors' profile. Instead, HER2-positive breast cancers are prone to be related to anti-Yo-associated paraneoplastic cerebellar disorders. Anti-onconeural antibodies positivity can be rarely found, confirming that paraneoplastic MND have no specific biomarkers. The presence of CSF oligoclonal bands (OBs) suggests the presence of immune-mediated mechanism, in absence of other possible OBs causes.
U2 - 10.1016/j.clineuro.2018.06.038
DO - 10.1016/j.clineuro.2018.06.038
M3 - Article
C2 - 30007590
VL - 172
SP - 141
EP - 142
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
SN - 0303-8467
ER -