Lower platelet count in healthy centenarians correlates with dispersion of the QT interval

Sebastiano Gangemi, Giorgio Basile, Rosaria Alba Merendino, Claudia Lo Balbo, Antonella Mento, Vittorio Nicita-Mauro, Claudio Franceschi, Mario Romano

Research output: Contribution to journalArticle

Abstract

Background and aims: Centenarians display a lower incidence of vascular ischemic events. A high platelet count and increased QT dispersion (QTd) represents a risk factor for cardiovascular events. The aim of this study was to evaluate platelet count and QTd in healthy centenarians and to establish correlations between these two indices. Methods: 16 healthy centenarians (4 males, 12 females, range 100-105 years) living in a municipality of Eastern Sicily, and 40 healthy control subjects, divided into two groups: group A (N=20), age range 45-65 years, 7 males, 13 females; and group B (N=20), range 65-85 years, 6 males, 14 females, were examined. Platelets were counted using a blood analyzer and QTd was measured in standard 12-lead electrocardiograms. Differences in platelet count were assessed by one-way analysis of variance (ANOVA) and the Bonferroni test. Correlation coefficients between platelet count and QTd were calculated with the Spearman rank test. Results: Centenarians showed a lower platelet count compared with controls, which was significant with respect to older controls, group B (p3. Conclusions: We hypothesize that a reduced number of platelets and the maintenance of normal QTd may contribute to extreme longevity and protect centenarians from cardiovascular events.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalAging clinical and experimental research
Volume16
Issue number2
Publication statusPublished - Apr 2004

Keywords

  • Aging
  • Centenarians
  • Platelet
  • QT dispersion

ASJC Scopus subject areas

  • Ageing

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    Gangemi, S., Basile, G., Merendino, R. A., Balbo, C. L., Mento, A., Nicita-Mauro, V., Franceschi, C., & Romano, M. (2004). Lower platelet count in healthy centenarians correlates with dispersion of the QT interval. Aging clinical and experimental research, 16(2), 169-171.