Lower serum zinc in relation to serum albumin and proinflammatory cytokines in detoxified alcohol-dependent patients without apparent liver disease

Nathalie De Vos, Cai Song, Ai Hua Lin, Paul Demedts, Annick Wauters, Hugo Neels, Raf De Jongh, Gunter Kenis, Eugene Bosmans, Carlo Altamura, Michael Maes

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, it was reported that there may be an activation of the inflammatory response system in detoxified alcohol-dependent patients without apparent liver disease (AWLD). The aims of the present study were to examine serum zinc (Zn) concentrations, total serum protein (TSP) and patterns obtained in the electrophoretically separated protein fractions in relation to serum interleukin-6 (IL-6) and IL-8 concentrations in detoxified AWLD patients. Zn, TSP, SP electrophoresis, and serum IL-6 and IL-8 concentrations were determined in detoxified AWLD patients and age-matched healthy volunteers. Serum Zn, TSP and the serum concentrations of albumin (Alb) and the β fraction were significantly lower in detoxified AWLD patients than in healthy volunteers. The percent age of the α2 fraction was significantly higher in detoxified AWLD patients. Lower serum Zn in detoxified AWLD patients was attributable to lowered serum Alb. Lower serum Alb was significantly and negatively correlated to increased serum IL-8. The percentage of the α1 and α2 fractions were significantly and positively related to serum IL-6 and IL-8. The results show that there is an in vivo activation of the inflammatory response system in detoxified AWLD patients and that lower serum Zn may be causally related to lower serum Alb.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalNeuropsychobiology
Volume39
Issue number3
Publication statusPublished - 1999

Keywords

  • Albumin
  • Alcohol dependence
  • Cholinesterase
  • Cytokines
  • Proteins
  • Zinc

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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