Lozenge is expressed in pluripotent precursor cells and patterns multiple cell types in the Drosophila eye through the control of cell-specific transcription factors

Gail V. Flores, Andrea Daga, Hamid R. Kalhor, Utpal Banerjee

Research output: Contribution to journalArticlepeer-review

Abstract

In the developing Drosophila eye, individual cell fates are specified when general signaling mechanisms are interpreted in the context of cell-specific transcription factors. Lozenge, a Runt/AML1/CBFA1-like transcription factor, determines the fates of a number of neuronal and non-neuronal cells by regulating the expression of multiple fate-determining transcription factors. The Lozenge protein is expressed in the nuclei of the cells that it patterns and also in their undifferentiated precursors. An enhancer element located within the second intron of the lozenge gene is responsible for its eye-specific expression. Lozenge is not itself a cell-specific transcription factor, rather it prepatterns the eye disc by positioning cell-specific factors in their appropriate locations.

Original languageEnglish
Pages (from-to)3681-3687
Number of pages7
JournalDevelopment
Volume125
Issue number18
Publication statusPublished - Sep 1998

Keywords

  • AML1
  • Drosophila
  • Eye development
  • Lozenge
  • Pattern formation
  • Runt
  • Signal transduction

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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