The authors investigated whether D LSD directly and selectively stimulates DA sensitive adenylate cyclase in striatum and in other areas of the limbic system which appears to be more strictly linked to perception, feeling and emotional behavior. Male Charles River rats, weighing 120-150 g, were used in the experiments. Adenylate cyclase activity was measured in the striatum, nucleus accumbens and tuberculum olfactorium, limbic cortex, cerebellum and retina following the method of Kebabian with minor modifications. The results give strong support to the hypothesis of a direct effect of D LSD on the DA sensitive adenylate cyclases which have been associated with the dopaminergic receptors in brain. This effect is apparent not only in the striatum but in those areas of the brain where dopaminergic terminals have been described, i.e., nucleus accumbens, tuberculum olfactorium and limbic cortex.
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