Luetic lymphadenopathy despite negative serology

F. Drago, E. Cinotti, C. Tomasini, A. Parodi

Research output: Contribution to journalArticle


misleading for the diagnosis of syphilis and false-negative results are possible, but it is rare for both treponemal and non-treponemal tests to prove negative in different stages of the disease. We report on a case of luetic lymphadenopathy, diagnosed by histological examination and supported by immunohistochemical staining for Treponema pallidum, in the absence of skin lesions and positive serology. This case reminds us of how syphilis may present in many different clinical forms and that it should not be excluded only on the basis of negative serological tests. This patient's negative serology was probably due to inadequate initial antibiotic therapy. Given the current widespread use of antibiotics, greater consideration is warranted of the extent to which serological test results are modified by non-specific antibiotic therapies.

Original languageEnglish
Pages (from-to)601-602
Number of pages2
JournalInternational Journal of STD and AIDS
Issue number8
Publication statusPublished - Aug 2012


  • Lymphadenopathy
  • Serology
  • Syphilis
  • TPHA
  • Treponema pallidum
  • VDRL

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Luetic lymphadenopathy despite negative serology'. Together they form a unique fingerprint.

  • Cite this