Luminal-like HER2-negative stage IA breast cancer: A multicenter retrospective study on long-term outcome with propensity score analysis

Carmine D. De Angelis, Massimo D. Di Maio, Anna Crispo, Mario Giuliano, Francesco Schettini, Marta Bonotto, Lorenzo Gerratana, Donatella Iacono, Marika Cinausero, Ferdinando Riccardi, Giuseppe Ciancia, Michelino De Laurentiis, Fabio Puglisi, Sabino D. De Placido, Grazia Arpino

Research output: Contribution to journalArticle

Abstract

The benefit of adding chemotherapy (CT) to adjuvant hormone therapy (HT) in stage IA luminal-like HER2-negative breast cancer (BC) is unclear. We retrospectively evaluated predictive factors and clinical outcome of 1,222 patients from 4 oncologic centers. Three hundred and eighty patients received CT and HT (CT-cohort) and 842 received HT alone (HT-cohort). Disease-free survival (DFS) and overall survival (OS) were evaluated with univariate and multivariate analyses. We also applied the propensity score methodology. Compared with the HT-cohort, patients in the CT-cohort were more likely to be younger, have larger tumors of a higher histological grade that were Ki67-positive, and lower estrogen and progesterone receptor expression. At univariate analysis, a higher histological grade and Ki67 were significantly associated to a lower DFS. At multivariable analysis, only histological grade was predictive of DFS. The CT-cohort had a worse outcome than the HT-cohort in terms of DFS and OS, but differences disappeared when matched according to propensity score. In summary, patients with stage IA luminal-like BC had an excellent prognosis, however relapse and mortality were higher in the CT-cohort than in the HT-cohort. Longer use of adjuvant HT or other therapeutic strategies may be needed to improve outcome.

Original languageEnglish
Pages (from-to)112816-112824
Number of pages9
JournalOncotarget
Volume8
Issue number68
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Breast cancer
  • Chemotherapy
  • Hormone therapy
  • Luminal-like
  • Propensity score

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    De Angelis, C. D., Di Maio, M. D., Crispo, A., Giuliano, M., Schettini, F., Bonotto, M., Gerratana, L., Iacono, D., Cinausero, M., Riccardi, F., Ciancia, G., Laurentiis, M. D., Puglisi, F., De Placido, S. D., & Arpino, G. (2017). Luminal-like HER2-negative stage IA breast cancer: A multicenter retrospective study on long-term outcome with propensity score analysis. Oncotarget, 8(68), 112816-112824. https://doi.org/10.18632/oncotarget.22643