Abstract
Fluorescence imaging techniques are becoming essential for preclinical investigations, necessitating the development of suitable tools for in vivo measurements. Nanotechnology entered this field to help overcome many of the current technical limitations, and luminescent nanoparticles (NPs) are one of the most promising materials proposed for future diagnostic implementation. NPs also constitute a versatile platform that can allow facile multi- functionalization to perform multimodal imaging or theranostics (simultaneous diagnosis and therapy). In this contribution we have mainly focused on dye doped silica or silica-based NPs conjugated with targeting moieties to enable imaging of specific cancer cells. We also cite and briefly discuss a few non-targeted systems for completeness. We summarize common synthetic approaches to these materials, and then survey the most recent imaging applications of silica-based nanoparticles in cancer. The field of theranostics is particularly important and stimulating, so, even though it is not the central topic of this paper, we have included some significant examples. We conclude with a short section on NP-based systems already in clinical trials and examples of specific applications in childhood tumors. This review aims to describe and discuss, through focused examples, the great potential of these materials in the medical field, with the aim to encourage further research to implement applications, which today are still rare.
| Original language | English |
|---|---|
| Pages (from-to) | 2195-2211 |
| Number of pages | 17 |
| Journal | Current Medicinal Chemistry |
| Volume | 20 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - Jun 2013 |
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Keywords
- Diagnostics
- Drug delivery
- Fluorescence
- Imaging
- Luminescence
- PEG
- Silica nanoparticles
- Theranostics
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
Cite this
Luminescent silica nanoparticles for cancer diagnosis. / Arap, W.; Pasqualini, R.; Montalti, M.; Petrizza, L.; Prodi, L.; Rampazzo, E.; Zaccheroni, N.; Marchió, S.
In: Current Medicinal Chemistry, Vol. 20, No. 17, 06.2013, p. 2195-2211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Luminescent silica nanoparticles for cancer diagnosis
AU - Arap, W.
AU - Pasqualini, R.
AU - Montalti, M.
AU - Petrizza, L.
AU - Prodi, L.
AU - Rampazzo, E.
AU - Zaccheroni, N.
AU - Marchió, S.
PY - 2013/6
Y1 - 2013/6
N2 - Fluorescence imaging techniques are becoming essential for preclinical investigations, necessitating the development of suitable tools for in vivo measurements. Nanotechnology entered this field to help overcome many of the current technical limitations, and luminescent nanoparticles (NPs) are one of the most promising materials proposed for future diagnostic implementation. NPs also constitute a versatile platform that can allow facile multi- functionalization to perform multimodal imaging or theranostics (simultaneous diagnosis and therapy). In this contribution we have mainly focused on dye doped silica or silica-based NPs conjugated with targeting moieties to enable imaging of specific cancer cells. We also cite and briefly discuss a few non-targeted systems for completeness. We summarize common synthetic approaches to these materials, and then survey the most recent imaging applications of silica-based nanoparticles in cancer. The field of theranostics is particularly important and stimulating, so, even though it is not the central topic of this paper, we have included some significant examples. We conclude with a short section on NP-based systems already in clinical trials and examples of specific applications in childhood tumors. This review aims to describe and discuss, through focused examples, the great potential of these materials in the medical field, with the aim to encourage further research to implement applications, which today are still rare.
AB - Fluorescence imaging techniques are becoming essential for preclinical investigations, necessitating the development of suitable tools for in vivo measurements. Nanotechnology entered this field to help overcome many of the current technical limitations, and luminescent nanoparticles (NPs) are one of the most promising materials proposed for future diagnostic implementation. NPs also constitute a versatile platform that can allow facile multi- functionalization to perform multimodal imaging or theranostics (simultaneous diagnosis and therapy). In this contribution we have mainly focused on dye doped silica or silica-based NPs conjugated with targeting moieties to enable imaging of specific cancer cells. We also cite and briefly discuss a few non-targeted systems for completeness. We summarize common synthetic approaches to these materials, and then survey the most recent imaging applications of silica-based nanoparticles in cancer. The field of theranostics is particularly important and stimulating, so, even though it is not the central topic of this paper, we have included some significant examples. We conclude with a short section on NP-based systems already in clinical trials and examples of specific applications in childhood tumors. This review aims to describe and discuss, through focused examples, the great potential of these materials in the medical field, with the aim to encourage further research to implement applications, which today are still rare.
KW - Diagnostics
KW - Drug delivery
KW - Fluorescence
KW - Imaging
KW - Luminescence
KW - PEG
KW - Silica nanoparticles
KW - Theranostics
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UR - http://www.scopus.com/inward/citedby.url?scp=84877949331&partnerID=8YFLogxK
U2 - 10.2174/0929867311320170005
DO - 10.2174/0929867311320170005
M3 - Article
VL - 20
SP - 2195
EP - 2211
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 17
ER -