Abstract
Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.
| Original language | English |
|---|---|
| Pages (from-to) | 467-477 |
| Number of pages | 11 |
| Journal | Scandinavian Journal of Work, Environment and Health |
| Volume | 41 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 5 2015 |
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Keywords
- Coal mining
- Histological subtype
- Mining
- Ore mining
- Population-based study
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Lung cancer among coal miners, ore miners and quarrymen : Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies. / Taeger, Dirk; Pesch, Beate; Kendzia, Benjamin; Behrens, Thomas; Jöckel, Karl Heinz; Dahmann, Dirk; Siemiatycki, Jack; Kromhout, Hans; Vermeulen, Roel; Peters, Susan; Olsson, Ann; Brüske, Irene; Wichmann, Heinz Erich; Stücker, Isabelle; Guida, Florence; Tardón, Adonina; Merletti, Franco; Mirabelli, Dario; Richiardi, Lorenzo; Pohlabeln, Hermann; Ahrens, Wolfgang; Landi, Maria Teresa; Caporaso, Neil; Pesatori, Angela Cecilia; Mukeriya, Anush; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Gustavsson, Per; Field, John; Marcus, Michael W.; Fabianova, Eleonora; Mannetje, Andrea‘ T.; Pearce, Neil; Rudnai, Peter; Bencko, Vladimir; Janout, Vladimir; Dumitru, Rodica Stanescu; Foretova, Lenka; Forastiere, Francesco; McLaughlin, John; Demers, Paul; Bueno-De-Mesquita, Bas; Schüz, Joachim; Straif, Kurt; Brüning, Thomas.
In: Scandinavian Journal of Work, Environment and Health, Vol. 41, No. 5, 05.09.2015, p. 467-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lung cancer among coal miners, ore miners and quarrymen
T2 - Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies
AU - Taeger, Dirk
AU - Pesch, Beate
AU - Kendzia, Benjamin
AU - Behrens, Thomas
AU - Jöckel, Karl Heinz
AU - Dahmann, Dirk
AU - Siemiatycki, Jack
AU - Kromhout, Hans
AU - Vermeulen, Roel
AU - Peters, Susan
AU - Olsson, Ann
AU - Brüske, Irene
AU - Wichmann, Heinz Erich
AU - Stücker, Isabelle
AU - Guida, Florence
AU - Tardón, Adonina
AU - Merletti, Franco
AU - Mirabelli, Dario
AU - Richiardi, Lorenzo
AU - Pohlabeln, Hermann
AU - Ahrens, Wolfgang
AU - Landi, Maria Teresa
AU - Caporaso, Neil
AU - Pesatori, Angela Cecilia
AU - Mukeriya, Anush
AU - Szeszenia-Dabrowska, Neonila
AU - Lissowska, Jolanta
AU - Gustavsson, Per
AU - Field, John
AU - Marcus, Michael W.
AU - Fabianova, Eleonora
AU - Mannetje, Andrea‘ T.
AU - Pearce, Neil
AU - Rudnai, Peter
AU - Bencko, Vladimir
AU - Janout, Vladimir
AU - Dumitru, Rodica Stanescu
AU - Foretova, Lenka
AU - Forastiere, Francesco
AU - McLaughlin, John
AU - Demers, Paul
AU - Bueno-De-Mesquita, Bas
AU - Schüz, Joachim
AU - Straif, Kurt
AU - Brüning, Thomas
PY - 2015/9/5
Y1 - 2015/9/5
N2 - Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.
AB - Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.
KW - Coal mining
KW - Histological subtype
KW - Mining
KW - Ore mining
KW - Population-based study
UR - http://www.scopus.com/inward/record.url?scp=84940870431&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940870431&partnerID=8YFLogxK
U2 - 10.5271/sjweh.3513
DO - 10.5271/sjweh.3513
M3 - Article
C2 - 26153779
AN - SCOPUS:84940870431
VL - 41
SP - 467
EP - 477
JO - Scandinavian Journal of Work, Environment and Health
JF - Scandinavian Journal of Work, Environment and Health
SN - 0355-3140
IS - 5
ER -