Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies

Dirk Taeger, Beate Pesch, Benjamin Kendzia, Thomas Behrens, Karl Heinz Jöckel, Dirk Dahmann, Jack Siemiatycki, Hans Kromhout, Roel Vermeulen, Susan Peters, Ann Olsson, Irene Brüske, Heinz Erich Wichmann, Isabelle Stücker, Florence Guida, Adonina Tardón, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Hermann PohlabelnWolfgang Ahrens, Maria Teresa Landi, Neil Caporaso, Angela Cecilia Pesatori, Anush Mukeriya, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Per Gustavsson, John Field, Michael W. Marcus, Eleonora Fabianova, Andrea‘ T. Mannetje, Neil Pearce, Peter Rudnai, Vladimir Bencko, Vladimir Janout, Rodica Stanescu Dumitru, Lenka Foretova, Francesco Forastiere, John McLaughlin, Paul Demers, Bas Bueno-De-Mesquita, Joachim Schüz, Kurt Straif, Thomas Brüning

Research output: Contribution to journalArticle

Abstract

Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

Original languageEnglish
Pages (from-to)467-477
Number of pages11
JournalScandinavian Journal of Work, Environment and Health
Volume41
Issue number5
DOIs
Publication statusPublished - Sep 5 2015

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Coal
Lung Neoplasms
Smoking
Odds Ratio
Confidence Intervals
Occupations
Miners
History

Keywords

  • Coal mining
  • Histological subtype
  • Mining
  • Ore mining
  • Population-based study

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Lung cancer among coal miners, ore miners and quarrymen : Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies. / Taeger, Dirk; Pesch, Beate; Kendzia, Benjamin; Behrens, Thomas; Jöckel, Karl Heinz; Dahmann, Dirk; Siemiatycki, Jack; Kromhout, Hans; Vermeulen, Roel; Peters, Susan; Olsson, Ann; Brüske, Irene; Wichmann, Heinz Erich; Stücker, Isabelle; Guida, Florence; Tardón, Adonina; Merletti, Franco; Mirabelli, Dario; Richiardi, Lorenzo; Pohlabeln, Hermann; Ahrens, Wolfgang; Landi, Maria Teresa; Caporaso, Neil; Pesatori, Angela Cecilia; Mukeriya, Anush; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Gustavsson, Per; Field, John; Marcus, Michael W.; Fabianova, Eleonora; Mannetje, Andrea‘ T.; Pearce, Neil; Rudnai, Peter; Bencko, Vladimir; Janout, Vladimir; Dumitru, Rodica Stanescu; Foretova, Lenka; Forastiere, Francesco; McLaughlin, John; Demers, Paul; Bueno-De-Mesquita, Bas; Schüz, Joachim; Straif, Kurt; Brüning, Thomas.

In: Scandinavian Journal of Work, Environment and Health, Vol. 41, No. 5, 05.09.2015, p. 467-477.

Research output: Contribution to journalArticle

Taeger, D, Pesch, B, Kendzia, B, Behrens, T, Jöckel, KH, Dahmann, D, Siemiatycki, J, Kromhout, H, Vermeulen, R, Peters, S, Olsson, A, Brüske, I, Wichmann, HE, Stücker, I, Guida, F, Tardón, A, Merletti, F, Mirabelli, D, Richiardi, L, Pohlabeln, H, Ahrens, W, Landi, MT, Caporaso, N, Pesatori, AC, Mukeriya, A, Szeszenia-Dabrowska, N, Lissowska, J, Gustavsson, P, Field, J, Marcus, MW, Fabianova, E, Mannetje, AT, Pearce, N, Rudnai, P, Bencko, V, Janout, V, Dumitru, RS, Foretova, L, Forastiere, F, McLaughlin, J, Demers, P, Bueno-De-Mesquita, B, Schüz, J, Straif, K & Brüning, T 2015, 'Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies', Scandinavian Journal of Work, Environment and Health, vol. 41, no. 5, pp. 467-477. https://doi.org/10.5271/sjweh.3513
Taeger, Dirk ; Pesch, Beate ; Kendzia, Benjamin ; Behrens, Thomas ; Jöckel, Karl Heinz ; Dahmann, Dirk ; Siemiatycki, Jack ; Kromhout, Hans ; Vermeulen, Roel ; Peters, Susan ; Olsson, Ann ; Brüske, Irene ; Wichmann, Heinz Erich ; Stücker, Isabelle ; Guida, Florence ; Tardón, Adonina ; Merletti, Franco ; Mirabelli, Dario ; Richiardi, Lorenzo ; Pohlabeln, Hermann ; Ahrens, Wolfgang ; Landi, Maria Teresa ; Caporaso, Neil ; Pesatori, Angela Cecilia ; Mukeriya, Anush ; Szeszenia-Dabrowska, Neonila ; Lissowska, Jolanta ; Gustavsson, Per ; Field, John ; Marcus, Michael W. ; Fabianova, Eleonora ; Mannetje, Andrea‘ T. ; Pearce, Neil ; Rudnai, Peter ; Bencko, Vladimir ; Janout, Vladimir ; Dumitru, Rodica Stanescu ; Foretova, Lenka ; Forastiere, Francesco ; McLaughlin, John ; Demers, Paul ; Bueno-De-Mesquita, Bas ; Schüz, Joachim ; Straif, Kurt ; Brüning, Thomas. / Lung cancer among coal miners, ore miners and quarrymen : Smoking-adjusted risk estimates from the synergy pooled analysis of case—control studies. In: Scandinavian Journal of Work, Environment and Health. 2015 ; Vol. 41, No. 5. pp. 467-477.
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abstract = "Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95{\%} confidence interval (95{\%} CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95{\%} CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95{\%} CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95{\%} CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.",
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T1 - Lung cancer among coal miners, ore miners and quarrymen

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AU - Taeger, Dirk

AU - Pesch, Beate

AU - Kendzia, Benjamin

AU - Behrens, Thomas

AU - Jöckel, Karl Heinz

AU - Dahmann, Dirk

AU - Siemiatycki, Jack

AU - Kromhout, Hans

AU - Vermeulen, Roel

AU - Peters, Susan

AU - Olsson, Ann

AU - Brüske, Irene

AU - Wichmann, Heinz Erich

AU - Stücker, Isabelle

AU - Guida, Florence

AU - Tardón, Adonina

AU - Merletti, Franco

AU - Mirabelli, Dario

AU - Richiardi, Lorenzo

AU - Pohlabeln, Hermann

AU - Ahrens, Wolfgang

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Pesatori, Angela Cecilia

AU - Mukeriya, Anush

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Gustavsson, Per

AU - Field, John

AU - Marcus, Michael W.

AU - Fabianova, Eleonora

AU - Mannetje, Andrea‘ T.

AU - Pearce, Neil

AU - Rudnai, Peter

AU - Bencko, Vladimir

AU - Janout, Vladimir

AU - Dumitru, Rodica Stanescu

AU - Foretova, Lenka

AU - Forastiere, Francesco

AU - McLaughlin, John

AU - Demers, Paul

AU - Bueno-De-Mesquita, Bas

AU - Schüz, Joachim

AU - Straif, Kurt

AU - Brüning, Thomas

PY - 2015/9/5

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N2 - Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

AB - Objectives Working in mines and quarries has been associated with an elevated lung cancer risk but with inconsistent results for coal miners. This study aimed to estimate the smoking-adjusted lung cancer risk among coal miners and compare the risk pattern with lung cancer risks among ore miners and quarrymen. Methods We estimated lung cancer risks of coal and ore miners and quarrymen among 14 251 lung cancer cases and 17 267 controls from the SYNERGY pooled case–control study, controlling for smoking and employment in other at-risk occupations. Results Ever working as miner or quarryman (690 cases, 436 controls) was associated with an elevated odds ratio (OR) of 1.55 [95% confidence interval (95% CI) 1.34–1.79] for lung cancer. Ore miners (53 cases, 24 controls) had a higher OR (2.34, 95% CI 1.36-4.03) than quarrymen (67 cases, 39 controls; OR 1.92, 95% CI 1.21–3.05) and coal miners (442 cases, 297 controls; OR 1.40, 95% CI 1.18–1.67), but CI overlapped. We did not observe trends by duration of exposure or time since last exposure. Conclusions This pooled analysis of population-based studies demonstrated an excess lung cancer risk among miners and quarrymen that remained increased after adjustment for detailed smoking history and working in other at-risk occupations. The increase in risk among coal miners were less pronounced than for ore miners or quarrymen.

KW - Coal mining

KW - Histological subtype

KW - Mining

KW - Ore mining

KW - Population-based study

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