Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies

Carolina Bigert, Per Gustavsson, Kurt Straif, Dirk Taeger, Beate Pesch, Benjamin Kendzia, Joachim Schüz, Isabelle Stücker, Florence Guida, Irene Brüske, Heinz Erich Wichmann, Angela C. Pesatori, Maria Teresa Landi, Neil Caporaso, Lap Ah Tse, Ignatius Tak Sun Yu, Jack Siemiatycki, Jérôme Lavoué, Lorenzo Richiardi, Dario MirabelliLorenzo Simonato, Karl Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Adonina Tardón, David Zaridze, John K. Field, Andrea'T Mannetje, Neil Pearce, John McLaughlin, Paul Demers, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Rodica Stanescu Dumitru, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Susan Peters, Roel Vermeulen, Hans Kromhout, Thomas Brüning, Ann C. Olsson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.

Original languageEnglish
Pages (from-to)1137-1143
Number of pages7
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number11
DOIs
Publication statusPublished - Nov 28 2016

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Firefighters
Case-Control Studies
Lung Neoplasms
Smoking
Social Adjustment
Occupational Exposure
New Zealand
Habits
Canada
China
Logistic Models
Odds Ratio

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Lung cancer among firefighters : Smoking-adjusted risk estimates in a pooled analysis of case-control studies. / Bigert, Carolina; Gustavsson, Per; Straif, Kurt; Taeger, Dirk; Pesch, Beate; Kendzia, Benjamin; Schüz, Joachim; Stücker, Isabelle; Guida, Florence; Brüske, Irene; Wichmann, Heinz Erich; Pesatori, Angela C.; Landi, Maria Teresa; Caporaso, Neil; Tse, Lap Ah; Yu, Ignatius Tak Sun; Siemiatycki, Jack; Lavoué, Jérôme; Richiardi, Lorenzo; Mirabelli, Dario; Simonato, Lorenzo; Jöckel, Karl Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Tardón, Adonina; Zaridze, David; Field, John K.; Mannetje, Andrea'T; Pearce, Neil; McLaughlin, John; Demers, Paul; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Rudnai, Peter; Fabianova, Eleonora; Dumitru, Rodica Stanescu; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Boffetta, Paolo; Peters, Susan; Vermeulen, Roel; Kromhout, Hans; Brüning, Thomas; Olsson, Ann C.

In: Journal of Occupational and Environmental Medicine, Vol. 58, No. 11, 28.11.2016, p. 1137-1143.

Research output: Contribution to journalArticle

Bigert, C, Gustavsson, P, Straif, K, Taeger, D, Pesch, B, Kendzia, B, Schüz, J, Stücker, I, Guida, F, Brüske, I, Wichmann, HE, Pesatori, AC, Landi, MT, Caporaso, N, Tse, LA, Yu, ITS, Siemiatycki, J, Lavoué, J, Richiardi, L, Mirabelli, D, Simonato, L, Jöckel, KH, Ahrens, W, Pohlabeln, H, Tardón, A, Zaridze, D, Field, JK, Mannetje, AT, Pearce, N, McLaughlin, J, Demers, P, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Dumitru, RS, Bencko, V, Foretova, L, Janout, V, Boffetta, P, Peters, S, Vermeulen, R, Kromhout, H, Brüning, T & Olsson, AC 2016, 'Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies', Journal of Occupational and Environmental Medicine, vol. 58, no. 11, pp. 1137-1143. https://doi.org/10.1097/JOM.0000000000000878
Bigert, Carolina ; Gustavsson, Per ; Straif, Kurt ; Taeger, Dirk ; Pesch, Beate ; Kendzia, Benjamin ; Schüz, Joachim ; Stücker, Isabelle ; Guida, Florence ; Brüske, Irene ; Wichmann, Heinz Erich ; Pesatori, Angela C. ; Landi, Maria Teresa ; Caporaso, Neil ; Tse, Lap Ah ; Yu, Ignatius Tak Sun ; Siemiatycki, Jack ; Lavoué, Jérôme ; Richiardi, Lorenzo ; Mirabelli, Dario ; Simonato, Lorenzo ; Jöckel, Karl Heinz ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Tardón, Adonina ; Zaridze, David ; Field, John K. ; Mannetje, Andrea'T ; Pearce, Neil ; McLaughlin, John ; Demers, Paul ; Szeszenia-Dabrowska, Neonila ; Lissowska, Jolanta ; Rudnai, Peter ; Fabianova, Eleonora ; Dumitru, Rodica Stanescu ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Boffetta, Paolo ; Peters, Susan ; Vermeulen, Roel ; Kromhout, Hans ; Brüning, Thomas ; Olsson, Ann C. / Lung cancer among firefighters : Smoking-adjusted risk estimates in a pooled analysis of case-control studies. In: Journal of Occupational and Environmental Medicine. 2016 ; Vol. 58, No. 11. pp. 1137-1143.
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abstract = "Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.",
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AU - Bigert, Carolina

AU - Gustavsson, Per

AU - Straif, Kurt

AU - Taeger, Dirk

AU - Pesch, Beate

AU - Kendzia, Benjamin

AU - Schüz, Joachim

AU - Stücker, Isabelle

AU - Guida, Florence

AU - Brüske, Irene

AU - Wichmann, Heinz Erich

AU - Pesatori, Angela C.

AU - Landi, Maria Teresa

AU - Caporaso, Neil

AU - Tse, Lap Ah

AU - Yu, Ignatius Tak Sun

AU - Siemiatycki, Jack

AU - Lavoué, Jérôme

AU - Richiardi, Lorenzo

AU - Mirabelli, Dario

AU - Simonato, Lorenzo

AU - Jöckel, Karl Heinz

AU - Ahrens, Wolfgang

AU - Pohlabeln, Hermann

AU - Tardón, Adonina

AU - Zaridze, David

AU - Field, John K.

AU - Mannetje, Andrea'T

AU - Pearce, Neil

AU - McLaughlin, John

AU - Demers, Paul

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Dumitru, Rodica Stanescu

AU - Bencko, Vladimir

AU - Foretova, Lenka

AU - Janout, Vladimir

AU - Boffetta, Paolo

AU - Peters, Susan

AU - Vermeulen, Roel

AU - Kromhout, Hans

AU - Brüning, Thomas

AU - Olsson, Ann C.

PY - 2016/11/28

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N2 - Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer. Results: There was no increased lung cancer risk overall or by specific cell type among firefighters (n=190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration. Conclusions: We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.

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