Lung cancer diagnosis on ovary mass: A case report

Nunzia Simona Losito, Cono Scaffa, Monica Cantile, Gerardo Botti, Raffaele Costanzo, Angela Manna, Renato Franco, Stefano Greggi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Metastatic neoplasms to the ovary often cause diagnostic problems, in particular those large ovarian masses mimicking primary tumors. Most of these tumors arise from digestive system or breast, while 37-year-old woman diagnosed as right adnexal complex mass, with a subpleural nodule in the apical part of the left lower lobe, at preoperative chest computed tomography scan. The patient underwent total abdominal hysterectomy with right salpingo-oophorectomy (ovarian mass 220 × 200 mm), total omentectomy, left ovarian biopsy, peritoneal random biopsies, and peritoneal washings for cytology. Pathologic and immunohistochemical examination of ovarian specimen suggested morphology and expression of metastatic lung adenocarcinoma with an intense positivity for Thyroid Transcriptional Factor-1 (TTF-1) and Cytokeratin 7 (CK7) staining. Fine needle biopsy of the lung nodule found epithelioid like malignant cells, confirming the diagnosis of an ovarian metastasis from a primary lung cancer. This report focused on the clinical and pathologic diagnostic challenge of distinguishing secondary from primary ovarian neoplasms. Issues on useful immunohistochemical stains are also discussed.

Original languageEnglish
Article number34
JournalJournal of Ovarian Research
Volume6
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Ovarian Neoplasms
Ovary
Lung Neoplasms
Keratin-7
Biopsy
Digestive System
Ovariectomy
Fine Needle Biopsy
Hysterectomy
Cell Biology
Neoplasms
Thyroid Gland
Breast
Coloring Agents
Thorax
Tomography
Staining and Labeling
Neoplasm Metastasis
Lung
Adenocarcinoma of lung

Keywords

  • Lung adenocarcinoma
  • Ovarian metastasis
  • Thyroid transcription factor 1

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Lung cancer diagnosis on ovary mass : A case report. / Losito, Nunzia Simona; Scaffa, Cono; Cantile, Monica; Botti, Gerardo; Costanzo, Raffaele; Manna, Angela; Franco, Renato; Greggi, Stefano.

In: Journal of Ovarian Research, Vol. 6, No. 1, 34, 2013.

Research output: Contribution to journalArticle

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AU - Franco, Renato

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