Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report

Daniela Bettio; Anna Venci; Valentina Achille; Marco Alloisio; Armando Santoro

doi:10.3892/etm.2015.2870

Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report

Daniela Bettio, Anna Venci, Valentina Achille, Marco Alloisio, Armando Santoro

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi‑step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array‑comparative genomic hybridization (a‑CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a‑CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi‑step carcinogenic process in the lung.

Original language	English
Pages (from-to)	98-100
Number of pages	3
Journal	Experimental and Therapeutic Medicine
Volume	11
Issue number	1
DOIs	https://doi.org/10.3892/etm.2015.2870
Publication status	Published - Jan 1 2016

Keywords

Adenomatous hyperplasia
Array-comparative genomic hybridization
Chromosome abnormalities
Lung cancer
Multi-step progression

ASJC Scopus subject areas

Medicine(all)
Cancer Research
Immunology and Microbiology (miscellaneous)

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abstract = "The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi‑step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array‑comparative genomic hybridization (a‑CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a‑CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi‑step carcinogenic process in the lung.",

keywords = "Adenomatous hyperplasia, Array-comparative genomic hybridization, Chromosome abnormalities, Lung cancer, Multi-step progression",

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AU - Bettio, Daniela

AU - Venci, Anna

AU - Achille, Valentina

AU - Alloisio, Marco

AU - Santoro, Armando

PY - 2016/1/1

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N2 - The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi‑step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array‑comparative genomic hybridization (a‑CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a‑CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi‑step carcinogenic process in the lung.

AB - The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi‑step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array‑comparative genomic hybridization (a‑CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a‑CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi‑step carcinogenic process in the lung.

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