Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report

Daniela Bettio, Anna Venci, Valentina Achille, Marco Alloisio, Armando Santoro

Research output: Contribution to journalArticlepeer-review

Abstract

The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi‑step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array‑comparative genomic hybridization (a‑CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a‑CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi‑step carcinogenic process in the lung.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalExperimental and Therapeutic Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Adenomatous hyperplasia
  • Array-comparative genomic hybridization
  • Chromosome abnormalities
  • Lung cancer
  • Multi-step progression

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Immunology and Microbiology (miscellaneous)

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