Lung cancer risk among refractory brick workers exposed to crystalline silica: A retrospective cohort study

Franco Merlo, Massimo Costantini, Giorgio Reggiardo, Marcello Ceppi, Riccardo Puntoni

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a retrospective cohort study among 1,022 refractory brick workers exposed to crystalline silica. Mortality from lung cancer (SMR = 1.77) and respiratory diseases (SMR = 3.15) was elevated in workers first employed ≤ 1957 who are likely to have shared the highest exposure to crystalline silica. Workers with at least 19 years of cumulative employment in the plant experienced particularly increased risks for lung cancer (SMR = 2.01) and respiratory diseases (SMR = 3.89). Relative mortality from these specific causes increased with years since first employment (that is, first exposure) and decreased with age at first employment. Indirect adjustment for smoking habits and the lack of excess mortality from cardiovascular diseases and emphysema indicated little effect of smoking on the increased risks for lung cancer and respiratory diseases.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalEpidemiology
Volume2
Issue number4
Publication statusPublished - 1991

Keywords

  • Cohort studies
  • Epidemiology
  • Lung cancer
  • Malignant neoplasms
  • Occupation
  • Silica
  • Smoking

ASJC Scopus subject areas

  • Epidemiology

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