Lung cancer stage is an independent risk factor for surgical mortality

Ugo Pastorino, Piero Borasio, Massimo Francese, Rosalba Miceli, Elisa Calabrò, Piergiorgio Solli, Francesco Leo, Silvia Novello, Giorgio Scagliotti, Luigi Mariani

Research output: Contribution to journalArticlepeer-review


Aims and background. To study surgical mortality and evaluate major risk factors, with specific focus on the role of pathological stage in patients undergoing lung cancer resection. Methods and study design.Age, gender, comorbidity, resection volume, experience of the hospital and surgical team have been reported as variables related to postoperative morbidity and mortality in lung cancer. The role of pathological tumor stage on postoperative mortality has never been fully evaluated. The study included 1418 consecutive lung cancer resections performed from 1998 to 2002 in two institutions. The effect of age, gender, comorbidity, resection volume, pathological stage and induction therapies on postoperative mortality was assessed by univariable and multivariable logistic regression analysis. Results. Postoperative mortality was 1.8% overall, 3.7% (9/243) for pneumonectomy, 1.7% (17/1016) for lobectomy, and null (0/159) for sublobar resections (P = 0.020). At multivariable analysis, cardiovascular comorbidity (P = 0.008), resection volume (P = 0.036) and pathological stage (P = 0.027) emerged as significant predictors of surgical mortality. Conclusions. Early stage lung cancer resection has a favorable effect on surgical mortality, not only by preventing the need for pneumonectomy, but also by reducing mortality after lobectomy.

Original languageEnglish
Pages (from-to)362-369
Number of pages8
Issue number3
Publication statusPublished - May 2008


  • Early stage
  • Lung cancer
  • Risk factor
  • Surgical mortality
  • Tumor size

ASJC Scopus subject areas

  • Cancer Research


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