Lung cancer stem cells: Tools and targets to fight lung cancer

A. Eramo, T. L. Haas, R. De Maria

Research output: Contribution to journalArticle

Abstract

Cancer stem cell (CSC) theory states that tumors are organized in a similar hierarchical manner as normal tissues, with a sub-population of tumorigenic stem-like cells that generate the more differentiated nontumorigenic tumor cells. CSCs are chemoresistant and seem to be responsible for tumor recurrence and formation of metastases. Therefore, the study of these cells may lead to crucial advances in the understanding of tumor biology as well as to innovative and more effective therapies. Lung cancer represents the leading cause of cancer-related mortality worldwide. Despite improvements in medical and surgical management, patient survival rates remain stable at∼15%, calling for innovative strategies that may contribute to improve patient outcome. The discovery of lung CSCs and the possibility to characterize their biological properties may provide powerful translational tools to improve the clinical outcome of patients with lung cancer. In this report, we review what is known about lung CSCs and discuss the diagnostic, prognostic and therapeutic prospective of these findings.

Original languageEnglish
Pages (from-to)4625-4635
Number of pages11
JournalOncogene
Volume29
Issue number33
DOIs
Publication statusPublished - Aug 19 2010

Keywords

  • cancer stem cells
  • lung cancer
  • stem cells
  • therapy

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics
  • Medicine(all)

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