Lung function impairment does not follow video assisted thoracoscopic lung biopsy for the diagnosis of interstitial lung disease

Z. Daniil, P. Pantelidis, U. Pastorino, R. M. Du Bois

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High resolution computed tomography has improved the diagnostic accuracy and prognosis in interstitial lung disease (ILD). However, lung biopsy is required if there is any uncertainty. In recent years Video-Assisted Thoracoscopic biopsy (VATS) has replaced Open Lung Biopsy (OLB) as the preferred approach. OLB may result in a decline of lung function tests. Aim: The purpose of this study was to investigate whether there is a deterioration in lung function following VATS for the diagnosis of ILD. Patients: In this retrospective study, lung function tests performed 1 to 2 months before VATS were compared with those performed 2 to 4 months after VATS in 33 patients (age range 23-74) 8 male and 25 female who had undergone VATS for the diagnosis of ILD between April 1993 and May 1997. Of these patients, 12 were receiving treatment for their disease at the time of the second lung function measurement and one was a current smoker. Results:No significant differences were observed in lung function tests performed before and after VATS (p>0.05) [mean percentage predicted values (±SD) before and after were: FEV1: 74.97 (±16.91) and 74.03 (±17.44); FVC: 77.03 (±19.82) and 76.27 (±20.65); TLC: 75.36 (±16.8) and 75.78 (±16.08); TLCO: 51.87 (±15.04) and 51.69 (±15.03); KCO: 77.15 (±14.59) and 79.48 (±15.47)]. No significant lung function impairment was observed when the population was stratified on the basis of disease severity (FVC

Original languageEnglish
Issue numberSUPPL. 6
Publication statusPublished - Dec 1997


ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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