Lung-seeking metastases

Giulia M. Stella, Stefan Kolling, Silvia Benvenuti, Chandra Bortolotto

Research output: Contribution to journalReview articlepeer-review


Metastases from different cancer types most often affect the lung parenchyma. Moreover, the lungs are among the most frequent sites of growth of metastatic masses of uncertain/unknown lineage of origin. Thus, with regards to pulmonary neoplastic parenchymal nodules, the critical issue is to determine if they are IN the lung or OF the lung. In this review, we highlight the clinical, instrumental and molecular features which characterize lung metastases, mainly focusing on recently advancing and emerging concepts regarding the metastatic niche, inflammation, angiogenesis, immune modulation and gene expression. A novel issue is related to the analysis of biomechanical forces which cooperate in the expansion of tumor masses in the lungs. We here aim to analyze the biological, genetic and pathological features of metastatic lesions to the lungs, here referred to as site of metastatic growth. This point should be a crucial part of the algorithm for a proper diagnostic and therapeutic approach in the era of personalized medicine.

Original languageEnglish
Article number1010
Issue number7
Publication statusPublished - Jul 1 2019


  • Biomarkers
  • Biomechanics
  • Lung
  • Metastases
  • Metastatic niche

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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