TY - JOUR
T1 - Lung stereotactic ablative body radiotherapy
T2 - A large scale multi-institutional planning comparison for interpreting results of multi-institutional studies
AU - Giglioli, Francesca Romana
AU - Strigari, Lidia
AU - Ragona, Riccardo
AU - Borzì, Giuseppina R.
AU - Cagni, Elisabetta
AU - Carbonini, Claudia
AU - Clemente, Stefania
AU - Consorti, Rita
AU - El Gawhary, Randa
AU - Esposito, Marco
AU - Falco, Maria Daniela
AU - Fedele, David
AU - Fiandra, Christian
AU - Frassanito, Maria Cristina
AU - Landoni, Valeria
AU - Loi, Gianfranco
AU - Lorenzini, Elena
AU - Malisan, Maria Rosa
AU - Marino, Carmelo
AU - Menghi, Enrico
AU - Nardiello, Barbara
AU - Nigro, Roberta
AU - Oliviero, Caterina
AU - Pastore, Gabriella
AU - Quattrocchi, Mariagrazia
AU - Ruggieri, Ruggero
AU - Redaelli, Irene
AU - Reggiori, Giacomo
AU - Russo, Serenella
AU - Villaggi, Elena
AU - Casati, Marta
AU - Mancosu, Pietro
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Purpose: A large-scale multi-institutional planning comparison on lung cancer SABR is presented with the aim of investigating possible criticism in carrying out retrospective multicentre data analysis from a dosimetric perspective. Methods: Five CT series were sent to the participants. The dose prescription to PTV was 54 Gy in 3 fractions of 18 Gy. The plans were compared in terms of PTV-gEUD2 (generalized Equivalent Uniform Dose equivalent to 2 Gy), mean dose to PTV, Homogeneity Index (PTV-HI), Conformity Index (PTV-CI) and Gradient Index (PTV-GI). We calculated the maximum dose for each OAR (organ at risk) considered as well as the MLD2 (mean lung dose equivalent to 2 Gy). The data were stratified according to expertise and technology. Results: Twenty-six centers equipped with Linacs, 3DCRT (4% - 1 center), static IMRT (8% - 2 centers), VMAT (76% - 20 centers), CyberKnife (4% - 1 center), and Tomotherapy (8% - 2 centers) collaborated. Significant PTV-gEUD2 differences were observed (range: 105-161 Gy); mean-PTV dose, PTV-HI, PTV-CI, and PTV-GI were, respectively, 56.8 ± 3.4 Gy, 14.2 ± 10.1%, 0.70 ± 0.15, and 4.9 ± 1.9. Significant correlations for PTV-gEUD2 versus PTV-HI, and MLD2 versus PTV-GI, were observed. Conclusions: The differences in terms of PTV-gEUD2 may suggest the inclusion of PTV-gEUD2 calculation for retrospective data inter-comparison.
AB - Purpose: A large-scale multi-institutional planning comparison on lung cancer SABR is presented with the aim of investigating possible criticism in carrying out retrospective multicentre data analysis from a dosimetric perspective. Methods: Five CT series were sent to the participants. The dose prescription to PTV was 54 Gy in 3 fractions of 18 Gy. The plans were compared in terms of PTV-gEUD2 (generalized Equivalent Uniform Dose equivalent to 2 Gy), mean dose to PTV, Homogeneity Index (PTV-HI), Conformity Index (PTV-CI) and Gradient Index (PTV-GI). We calculated the maximum dose for each OAR (organ at risk) considered as well as the MLD2 (mean lung dose equivalent to 2 Gy). The data were stratified according to expertise and technology. Results: Twenty-six centers equipped with Linacs, 3DCRT (4% - 1 center), static IMRT (8% - 2 centers), VMAT (76% - 20 centers), CyberKnife (4% - 1 center), and Tomotherapy (8% - 2 centers) collaborated. Significant PTV-gEUD2 differences were observed (range: 105-161 Gy); mean-PTV dose, PTV-HI, PTV-CI, and PTV-GI were, respectively, 56.8 ± 3.4 Gy, 14.2 ± 10.1%, 0.70 ± 0.15, and 4.9 ± 1.9. Significant correlations for PTV-gEUD2 versus PTV-HI, and MLD2 versus PTV-GI, were observed. Conclusions: The differences in terms of PTV-gEUD2 may suggest the inclusion of PTV-gEUD2 calculation for retrospective data inter-comparison.
KW - Dosimetry
KW - Lung
KW - Multicentric clinical trial
KW - Radiobiology
KW - Stereotactic ablative radiotherapy (SABR)
KW - Stereotactic body radiation therapy (SBRT)
UR - http://www.scopus.com/inward/record.url?scp=84962440794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962440794&partnerID=8YFLogxK
U2 - 10.1016/j.ejmp.2016.03.015
DO - 10.1016/j.ejmp.2016.03.015
M3 - Article
AN - SCOPUS:84962440794
VL - 32
SP - 600
EP - 606
JO - Physica Medica
JF - Physica Medica
SN - 1120-1797
IS - 4
ER -