Lung structure and function in different stages of severe adult respiratory distress syndrome

Luciano Gattinoni, Michela Bombino, Paolo Pelosi, Alfredo Lissoni, Antonio Pesenti, Roberto Fumagalli, Marcello Tagliabue

Research output: Contribution to journalArticlepeer-review


Objective. - To assess the clinical consequences of duration of adult respiratory distress syndrome (ARDS) on lung structure and function. Design. - Retrospective analysis. Setting. - A university hospital referral center for extracorporeal support. Patients. - A total of 84 patients with severe ARDS (Murray score >2.5) recruited from 48 intensive care units (1979 to 1992), who suffered ARDS and underwent mechanical ventilation for up to 1 week (37 patients with early ARDS), between 1 and 2 weeks (24 patients with intermediate ARDS), or more than 2 weeks (23 patients with late ARDS) and subsequently underwent extracorporeal support. Main Outcome Measures. - Before beginning extracorporeal support, we measured gas exchange, pulmonary mechanics, hemodynamics, oxygen transport and delivery, incidence of barotrauma (presence of one or more thoracic tubes for pneumothorax drainage), and organ dysfunctions. In a subgroup of 16 patients, we studied lung structure by computed tomographic scan, scoring the densities and quantifying the emphysemalike lesions (bullae). Results. - Late ARDS showed lower respiratory compliance, higher dead space, higher PaCO2, lower venous admixture, and lower positive end-expiratory pressure requirement compared with early ARDS (P

Original languageEnglish
Pages (from-to)1772-1779
Number of pages8
JournalJournal of the American Medical Association
Issue number22
Publication statusPublished - Jun 8 1994

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Lung structure and function in different stages of severe adult respiratory distress syndrome'. Together they form a unique fingerprint.

Cite this