Lung transplantation and posterior reversible encephalopathy syndrome: A case series

Research output: Contribution to journalArticle

Abstract

Posterior reversible encephalopathy syndrome is a neurological problem characterized by headache, altered mental status, focal neurological deficits, visual disorders, and seizures. The disorder is related to a number of diseases including calcineurin inhibitor therapy in solid organ transplantation. The incidence of posterior reversible encephalopathy syndrome in lung transplantation patients is unclear; probably the majority of the cases are unreported. The authors have described a case series constituted of four patients presenting posterior reversible encephalopathy syndrome after bilateral lung transplantation. The cases had in common complicated surgery and a posttransplant course characterized by hypertension, hypomagnesemia and acidosis. Invasive mechanical ventilation, calcineurin inhibitor discontinuation, aggressive antihypertensive therapy, and electrolyte regulation led to near complete recovery of symptoms.

Original languageEnglish
Pages (from-to)2022-2025
Number of pages4
JournalTransplantation Proceedings
Volume44
Issue number7
DOIs
Publication statusPublished - Sep 2012

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Posterior Leukoencephalopathy Syndrome
Lung Transplantation
Vision Disorders
Organ Transplantation
Acidosis
Artificial Respiration
Antihypertensive Agents
Electrolytes
Headache
Seizures
Hypertension
Incidence
Therapeutics
Calcineurin Inhibitors

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

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abstract = "Posterior reversible encephalopathy syndrome is a neurological problem characterized by headache, altered mental status, focal neurological deficits, visual disorders, and seizures. The disorder is related to a number of diseases including calcineurin inhibitor therapy in solid organ transplantation. The incidence of posterior reversible encephalopathy syndrome in lung transplantation patients is unclear; probably the majority of the cases are unreported. The authors have described a case series constituted of four patients presenting posterior reversible encephalopathy syndrome after bilateral lung transplantation. The cases had in common complicated surgery and a posttransplant course characterized by hypertension, hypomagnesemia and acidosis. Invasive mechanical ventilation, calcineurin inhibitor discontinuation, aggressive antihypertensive therapy, and electrolyte regulation led to near complete recovery of symptoms.",
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AU - Rosso, L.

AU - Nosotti, M.

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AU - Tosi, D.

AU - Montoli, M.

AU - Pappalettera, M.

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