Lung transplantation for cystic fibrosis: Outcome of 101 single-center consecutive patients

D. Diso, M. Anile, M. Patella, Y. Pecoraro, E. A. Rendina, C. Carillo, E. Russo, I. Onorati, D. Angioletti, F. Ruberto, G. Mazzesi, A. G M Marullo, G. Frati, F. Venuta

Research output: Contribution to journalArticle

Abstract

Bilateral sequential lung transplantation (BSLT) is nowadays considered a valid therapeutic option for patients with end stage cystic fibrosis. We report our experience with 104 BSLTs in 101 patients. The overall survivals at 1, 3, 5, 10 years were 79%, 65%, 58%, and 42%, respectively. Perioperative mortality was 14.8% (n = 15). The leading causes of perioperative mortality were primary graft dysfunction and sepsis. Three patients were retransplanted owing to obliterative bronchiolitis. In 70 cases (69%), patients displayed ≥1 additional risk factors: previous lung resections, colonization by Burkholderia cepacia, diabetes, pneumothorax, or noninvasive ventilatory support. The mean preoperative 1-second forced expiratory volume of 0.69 ± 0.2 L (22%) increased to 85% at 1 year after the operation. The mean time on the waiting list was 12 ± 5 months. The 5 patients treated with extracorporeal membrane oxygenation before urgent transplantation were operated after 3, 5, 6, 30, and 3 days respectively. During the procedure, cardiopulmonary bypass was required in 33 patients (32%). Lung transplantation represents a unique opportunity to ameliorate the quality and improve the survival of patients affected by cystic fibrosis. Timing of referral and patient selection remain crucial for success.

Original languageEnglish
Pages (from-to)346-348
Number of pages3
JournalTransplantation Proceedings
Volume45
Issue number1
DOIs
Publication statusPublished - Jan 2013

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Diso, D., Anile, M., Patella, M., Pecoraro, Y., Rendina, E. A., Carillo, C., Russo, E., Onorati, I., Angioletti, D., Ruberto, F., Mazzesi, G., Marullo, A. G. M., Frati, G., & Venuta, F. (2013). Lung transplantation for cystic fibrosis: Outcome of 101 single-center consecutive patients. Transplantation Proceedings, 45(1), 346-348. https://doi.org/10.1016/j.transproceed.2012.08.010