Lupus anticoagulant and monocyte procoagulant activity in polyabortive women

B. Giusti, A. M. Gori, M. Attanasio, F. Martini, M. Boddi, C. Livi, G. Massai, M. M. D'elios, T. Brunelli, R. Abbate

Research output: Contribution to journalArticlepeer-review

Abstract

Monocyte stimulation may be induced by various agents. Monocytes generate procoagulant activity (PCA) in response to stimulation; they widely interact with the hemostatic system and participate in thrombin formation. Extensive placental thrombotic infarction has been implicated in fetal death in poly abortive patients with lupus anticoagulant (LA). We investigated 38 polyabortive women: 17 LA negative (LA-) and 18 LA positive (LA+ We compared the results with 25 clinically normal women. After four hours of incubation, the mean value of monocyte PCA in the LA+ women was significantly higher than in either the LA- or the control group (p <0.0001). The monocyte PCA was out of the range of the controls in 9 of the 18 LA+ women. No correlation was observed between the levels of LA and monocyte PCA (r = 0.02; p = 0.94). No differences were found in monocyte PCA increase when induced by LA-, LA+ or control plasma; in all cases the increase was about five-six fold. Our results indicate that an increased monocyte PCA is present in some LA+ polyabortive women, thus suggesting that monocyte activation might be involved in the formation of thrombotic placental infarction and the consequent fetal loss in some patients. It might also suggest that these patients, in particular, could benefit from corticosteroid treatment, which is known to inhibit the formation of monocyte PCA.

Original languageEnglish
Pages (from-to)299-304
Number of pages6
JournalAutoimmunity
Volume15
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • Antiphospholipid antibodies
  • Plasma
  • Procoagulant activity
  • Recurrent abortion

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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