TY - JOUR
T1 - Lupus anticoagulant positivity in insulin dependent diabetic patients
T2 - An additional risk factor in the pathogenesis of diabetic retinopathy?
AU - Giusti, Cristiano
AU - Schiaffini, Riccardo
AU - Bosco, Daniela
AU - Ciampalini, Paolo
AU - Pantaleo, Antonio
AU - Vingolo, Enzo M.
AU - Gargiulo, Patrizia
PY - 2000/5
Y1 - 2000/5
N2 - Aims - To investigate whether lupus anticoagulant (LA) positivity, a marker of endothelial dysfunction, might be relevant to the pathogenesis of diabetic retinopathy (DR). Methods - 32 IDDM patients were examined for LA, fibrinogen, prothrombin (PT), PTT, prothrombin degradation products (F1 + 2), and activated protein C (APC). Results - APC decreased and F1 + 2 increased significantly in LA positive but not in LA negative patients; 60% of LA positive and 18% of LA negative subjects had DR. PT, PTT, and fibrinogen levels were insignificant. Conclusion - These preliminary findings suggest that LA positivity could represent an additional risk factor for DR, acting as a link between the immunological and haemostatic systems.
AB - Aims - To investigate whether lupus anticoagulant (LA) positivity, a marker of endothelial dysfunction, might be relevant to the pathogenesis of diabetic retinopathy (DR). Methods - 32 IDDM patients were examined for LA, fibrinogen, prothrombin (PT), PTT, prothrombin degradation products (F1 + 2), and activated protein C (APC). Results - APC decreased and F1 + 2 increased significantly in LA positive but not in LA negative patients; 60% of LA positive and 18% of LA negative subjects had DR. PT, PTT, and fibrinogen levels were insignificant. Conclusion - These preliminary findings suggest that LA positivity could represent an additional risk factor for DR, acting as a link between the immunological and haemostatic systems.
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U2 - 10.1136/bjo.84.5.531
DO - 10.1136/bjo.84.5.531
M3 - Article
C2 - 10781520
AN - SCOPUS:0034100892
VL - 84
SP - 531
EP - 533
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 5
ER -