Lupus anticoagulant testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT)

Armando Tripodi, Veena Chantarangkul

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Actvated partial thromboplastin time and its congener test Silica clotting time are used for the laboratory detection of lupus anticoagulants. Their performance consists of mixing test plasma with activators of the contact coagulation factors, phospholipids and calcium chloride, and recording the clotting time. Here we describe the principle, performance and extensive practical details of the two methods, the problems that may be encountered and how they can be identified and overcome.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages177-183
Number of pages7
Volume1646
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1646
ISSN (Print)1064-3745

Keywords

  • Activated partial thromboplastin time
  • Antiphosphoilpid syndrome
  • Laboratory test
  • Silica clotting time
  • Thrombosis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Tripodi, A., & Chantarangkul, V. (2017). Lupus anticoagulant testing: Activated Partial Thromboplastin Time (APTT) and Silica Clotting Time (SCT). In Methods in Molecular Biology (Vol. 1646, pp. 177-183). (Methods in Molecular Biology; Vol. 1646). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7196-1_15