There are very scarce data in the literature regarding prevalence, risk factors and clinical significance of lupus anticoagulant (LA) antibodies among chronic haemodialysis (RD) patients. We studied the presence of lupus anticoagulants in 101 patients with end-stage renal failure on chronic HD treatment. Four of them showed LA antibodies (4%). We did not observe association between LA risk factors such as: gender, age, duration of HD treatment, underlying nephropathies and drugs received. We did not find association between LA and long-term use of bioincompatible membranes. The frequency of patients with multiple arteriovenous graft thromboses was higher in LA positive than in LA negative patients but the difference was not significant. We conclude that the prevalence of LA is slightly higher in our HD patients compared to the general population. Thus LA autoantibodies appear to be epiphenomena rather than features of dialysis membrane bioincompatibility. LA can be associated with frequent hemodialysis graft thrombosis but their pathogenetic role deserves further studies.
|Translated title of the contribution||Lupus anticoagulants (LA) antibodies among chronic haemodialysis patients: Prevalence and risk factors|
|Number of pages||8|
|Journal||Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia|
|Publication status||Published - 1995|
ASJC Scopus subject areas