Abstract
The occurrence of erythema multiforme (EM) in patients with lupus erythematosus (LE) has been described previously as a coincidental association. In contrast, LE with EM-like lesions and a peculiar immunological pattern, including positive rheumatoid factor, antinuclear antibodies and a serum antibody against an extract of human tissues recently recognized as similar to Ro (SSA), constitutes an established entity named Rowell's syndrome. We describe a woman with LE and long-standing widespread vesiculobullous and necrotic haemorrhagic EM-like lesions in combination with Ro (SSA) and scl-70 antibodies and the typical laboratory findings of the antiphospholipid syndrome (APS), namely lupus anticoagulant, anticardiolipin antibodies and prolonged activated partial thromboplastin time. This case could conceivably be consistent with a diagnosis of Rowell's syndrome, if the latter is regarded as a clinicopathological spectrum. However, the coexistence of LE, persistent EM-like disease and incomplete APS may also fulfil the diagnostic criteria for the 'multiple autoimmune syndromes'. We speculate that the laboratory markers of APS play a pivotal part in such an unusual clinical presentation.
| Original language | English |
|---|---|
| Pages (from-to) | 720-724 |
| Number of pages | 5 |
| Journal | British Journal of Dermatology |
| Volume | 141 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Antiphospholipid syndrome
- Erythema multiforme
- Lupus erythematosus
- Multiple autoimmune syndromes
- Rowell's syndrome
ASJC Scopus subject areas
- Dermatology
Cite this
Lupus erythematosus with antiphospholipid syndrome and erythema multiforme-like lesions. / Marzano, A. V.; Berti, E.; Gasparini, G.; Caputo, R.
In: British Journal of Dermatology, Vol. 141, No. 4, 1999, p. 720-724.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lupus erythematosus with antiphospholipid syndrome and erythema multiforme-like lesions
AU - Marzano, A. V.
AU - Berti, E.
AU - Gasparini, G.
AU - Caputo, R.
PY - 1999
Y1 - 1999
N2 - The occurrence of erythema multiforme (EM) in patients with lupus erythematosus (LE) has been described previously as a coincidental association. In contrast, LE with EM-like lesions and a peculiar immunological pattern, including positive rheumatoid factor, antinuclear antibodies and a serum antibody against an extract of human tissues recently recognized as similar to Ro (SSA), constitutes an established entity named Rowell's syndrome. We describe a woman with LE and long-standing widespread vesiculobullous and necrotic haemorrhagic EM-like lesions in combination with Ro (SSA) and scl-70 antibodies and the typical laboratory findings of the antiphospholipid syndrome (APS), namely lupus anticoagulant, anticardiolipin antibodies and prolonged activated partial thromboplastin time. This case could conceivably be consistent with a diagnosis of Rowell's syndrome, if the latter is regarded as a clinicopathological spectrum. However, the coexistence of LE, persistent EM-like disease and incomplete APS may also fulfil the diagnostic criteria for the 'multiple autoimmune syndromes'. We speculate that the laboratory markers of APS play a pivotal part in such an unusual clinical presentation.
AB - The occurrence of erythema multiforme (EM) in patients with lupus erythematosus (LE) has been described previously as a coincidental association. In contrast, LE with EM-like lesions and a peculiar immunological pattern, including positive rheumatoid factor, antinuclear antibodies and a serum antibody against an extract of human tissues recently recognized as similar to Ro (SSA), constitutes an established entity named Rowell's syndrome. We describe a woman with LE and long-standing widespread vesiculobullous and necrotic haemorrhagic EM-like lesions in combination with Ro (SSA) and scl-70 antibodies and the typical laboratory findings of the antiphospholipid syndrome (APS), namely lupus anticoagulant, anticardiolipin antibodies and prolonged activated partial thromboplastin time. This case could conceivably be consistent with a diagnosis of Rowell's syndrome, if the latter is regarded as a clinicopathological spectrum. However, the coexistence of LE, persistent EM-like disease and incomplete APS may also fulfil the diagnostic criteria for the 'multiple autoimmune syndromes'. We speculate that the laboratory markers of APS play a pivotal part in such an unusual clinical presentation.
KW - Antiphospholipid syndrome
KW - Erythema multiforme
KW - Lupus erythematosus
KW - Multiple autoimmune syndromes
KW - Rowell's syndrome
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UR - http://www.scopus.com/inward/citedby.url?scp=0032692575&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2133.1999.03118.x
DO - 10.1046/j.1365-2133.1999.03118.x
M3 - Article
C2 - 10583125
AN - SCOPUS:0032692575
VL - 141
SP - 720
EP - 724
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 4
ER -