LXR-dependent and -independent effects of oxysterols on immunity and tumor growth

Catia Traversari, Silvano Sozzani, Knut R. Steffensen, Vincenzo Russo

Research output: Contribution to journalArticle

Abstract

Oxysterols are involved in maintaining cellular cholesterol levels. Recently, oxysterols have been demonstrated to modulate the function of immune cells and tumor growth. These effects can be dependent on the activation of the oxysterol-binding liver X receptors (LXRs) or, as recently demonstrated for T and B cells, DCs and neutrophils, can be independent of LXR activation. LXR-dependent oxysterol effects can be ascribed to the activation of LXRα, LXRβ or LXRαβ isoforms, which induces transcriptional activation or trans-repression of target genes. The prevalent activation of one isoform seems to be cell-, tissue-, or context-specific, as shown in some pathologic processes, i.e., infectious diseases, atherosclerosis, and autoimmunity. Oxysterol-LXR signaling has recently been shown to inhibit antitumor immune responses, as well as to modulate tumor cell growth. Here, we review the mechanisms that link oxysterols to tumor growth, and discuss possible networks at the basis of LXR-dependent and -independent oxysterol effects on immune cells and tumor development.

Original languageEnglish
Pages (from-to)1896-1903
Number of pages8
JournalEuropean Journal of Immunology
Volume44
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • Antitumor immune responses
  • Liver X receptor(s)
  • Oxysterols

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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