Abstract
Oxysterols are involved in maintaining cellular cholesterol levels. Recently, oxysterols have been demonstrated to modulate the function of immune cells and tumor growth. These effects can be dependent on the activation of the oxysterol-binding liver X receptors (LXRs) or, as recently demonstrated for T and B cells, DCs and neutrophils, can be independent of LXR activation. LXR-dependent oxysterol effects can be ascribed to the activation of LXRα, LXRβ or LXRαβ isoforms, which induces transcriptional activation or trans-repression of target genes. The prevalent activation of one isoform seems to be cell-, tissue-, or context-specific, as shown in some pathologic processes, i.e., infectious diseases, atherosclerosis, and autoimmunity. Oxysterol-LXR signaling has recently been shown to inhibit antitumor immune responses, as well as to modulate tumor cell growth. Here, we review the mechanisms that link oxysterols to tumor growth, and discuss possible networks at the basis of LXR-dependent and -independent oxysterol effects on immune cells and tumor development.
| Original language | English |
|---|---|
| Pages (from-to) | 1896-1903 |
| Number of pages | 8 |
| Journal | European Journal of Immunology |
| Volume | 44 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Antitumor immune responses
- Liver X receptor(s)
- Oxysterols
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
LXR-dependent and -independent effects of oxysterols on immunity and tumor growth. / Traversari, Catia; Sozzani, Silvano; Steffensen, Knut R.; Russo, Vincenzo.
In: European Journal of Immunology, Vol. 44, No. 7, 2014, p. 1896-1903.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - LXR-dependent and -independent effects of oxysterols on immunity and tumor growth
AU - Traversari, Catia
AU - Sozzani, Silvano
AU - Steffensen, Knut R.
AU - Russo, Vincenzo
PY - 2014
Y1 - 2014
N2 - Oxysterols are involved in maintaining cellular cholesterol levels. Recently, oxysterols have been demonstrated to modulate the function of immune cells and tumor growth. These effects can be dependent on the activation of the oxysterol-binding liver X receptors (LXRs) or, as recently demonstrated for T and B cells, DCs and neutrophils, can be independent of LXR activation. LXR-dependent oxysterol effects can be ascribed to the activation of LXRα, LXRβ or LXRαβ isoforms, which induces transcriptional activation or trans-repression of target genes. The prevalent activation of one isoform seems to be cell-, tissue-, or context-specific, as shown in some pathologic processes, i.e., infectious diseases, atherosclerosis, and autoimmunity. Oxysterol-LXR signaling has recently been shown to inhibit antitumor immune responses, as well as to modulate tumor cell growth. Here, we review the mechanisms that link oxysterols to tumor growth, and discuss possible networks at the basis of LXR-dependent and -independent oxysterol effects on immune cells and tumor development.
AB - Oxysterols are involved in maintaining cellular cholesterol levels. Recently, oxysterols have been demonstrated to modulate the function of immune cells and tumor growth. These effects can be dependent on the activation of the oxysterol-binding liver X receptors (LXRs) or, as recently demonstrated for T and B cells, DCs and neutrophils, can be independent of LXR activation. LXR-dependent oxysterol effects can be ascribed to the activation of LXRα, LXRβ or LXRαβ isoforms, which induces transcriptional activation or trans-repression of target genes. The prevalent activation of one isoform seems to be cell-, tissue-, or context-specific, as shown in some pathologic processes, i.e., infectious diseases, atherosclerosis, and autoimmunity. Oxysterol-LXR signaling has recently been shown to inhibit antitumor immune responses, as well as to modulate tumor cell growth. Here, we review the mechanisms that link oxysterols to tumor growth, and discuss possible networks at the basis of LXR-dependent and -independent oxysterol effects on immune cells and tumor development.
KW - Antitumor immune responses
KW - Liver X receptor(s)
KW - Oxysterols
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UR - http://www.scopus.com/inward/citedby.url?scp=84904400209&partnerID=8YFLogxK
U2 - 10.1002/eji.201344292
DO - 10.1002/eji.201344292
M3 - Article
C2 - 24777958
AN - SCOPUS:84904400209
VL - 44
SP - 1896
EP - 1903
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 7
ER -