Lycopene minimizes skin toxicity and oxidative stress in patients treated with panitumumab-containing therapy for metastatic colorectal cancer

Mauro Moroni, Marco Pirovano, Silvia Brugnatelli, Martina Zucca, Marco Morreale, Vittoria Rizzo, Alessandra Ferrari, Carmine Tinelli, Annalisa De Silvestri, Maurizio Meregalli, Monica Giordano, Salvatore Artale, Massimiliano Cergnul, Roberto Bollina, Mimma Rizzo, Paolo Pedrazzoli

Research output: Contribution to journalArticlepeer-review

Abstract

Epidermal Growth Factor Receptor (EGFR) inhibition leads to the production of reactive oxygen metabolites causing skin inflammatory reactions. Anti-EGFR therapies are frequently associated with skin toxicities which often cause treatment delay and impairment to patient quality of life. Lycopene is a compound in the carotenoid group with an extreme antioxidant action which accumulates in the skin due to its hydrophobic structure. In a pilot study, we describe lactolycopene effectiveness in reducing skin toxicity and protecting tissues from oxidative stress in patients treated with panitumumab. Despite the limited number of patients, we show an absolute reduction of skin grade 2–3 toxicity in 41% of patients and 46% of panitumumab cumulative cycles in the experimental group versus placebo; lactolycopene administration was able to abolish malondialdehyde (MDA) production, a biomarker used to measure lipid peroxidation in the organism, and replenish antioxidant consumption in the course of anti-EGFR therapy. Trial registration: Clinicaltrials.gov NCT 03,167,268 (Pasto trial).

Original languageEnglish
Article number104533
JournalJournal of Functional Foods
Volume83
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Anti-EGFR drugs
  • Antioxidant
  • EGFR inhibition
  • Malondialdhyde
  • β -carotene

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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