TY - JOUR
T1 - Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-γ
AU - De Stefano, Daniela
AU - Maiuri, Maria Chiara
AU - Simeon, Vittorio
AU - Grassia, Gianluca
AU - Soscia, Antonio
AU - Cinelli, Maria Pia
AU - Carnuccio, Rosa
PY - 2007/7/2
Y1 - 2007/7/2
N2 - Oxidative stress plays an important role in inflammatory process of celiac disease. We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-γ. The IFN-γ plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-κB (NF-κB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1α (STAT-1α) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects. The results here reported suggest that these compounds may represent non toxic agents for the control of pro-inflammatory genes involved in celiac disease.
AB - Oxidative stress plays an important role in inflammatory process of celiac disease. We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-γ. The IFN-γ plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-κB (NF-κB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1α (STAT-1α) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects. The results here reported suggest that these compounds may represent non toxic agents for the control of pro-inflammatory genes involved in celiac disease.
KW - Celiac disease
KW - Gliadin
KW - Interferon-gamma
KW - RAW 264.7 macrophage
KW - Transcription factors
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U2 - 10.1016/j.ejphar.2007.03.051
DO - 10.1016/j.ejphar.2007.03.051
M3 - Article
C2 - 17477920
AN - SCOPUS:34249048898
VL - 566
SP - 192
EP - 199
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-3
ER -