Lymph node involvement in T1 non-small-cell lung cancer: Could glucose uptake and maximal diameter be predictive criteria?

Research output: Contribution to journalArticle

Abstract

Objective: The introduction of modern staging systems such as computed tomography (CT) and positron emission tomography/CT (PET/CT) with fluorodeoxyglucose ([18F]FDG) has increased the detection of small peripheral lung cancers at an early stage. We analyzed the behavior of pathological T1 non-small-cell lung cancer (NSCLC) to identify criteria predictive of nodal involvement, and the role of cancer size in lymph node metastases. Methods: We retrospectively analyzed 219 patients with pathological T1 NSCLC. All patients were staged by high-resolution CT and PET as stage I, and underwent anatomical resection and radical lymphadenectomy. Our data were collected based on pathological nodule size (0-10mm; 11-20mm; and 21-30mm); morphological features of lung nodule and FDG uptake of the tumor measured by standardized uptake value (SUV). Results: A total of 190 patients (87%) were pN0, 14 (6%) pN1, and 15 (7%) pN2. No nodal involvement was observed in any of the 62 patients with nodule size less than 10mm, in 20 out of 120 patients (17%) with nodule size 11-20mm, and in nine out of 37 tumors (28%) 21-30mm in size (p=0.0007). All 55 patients with nodule SUV

Original languageEnglish
JournalEuropean Journal of Cardio-thoracic Surgery
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Fluorodeoxyglucose
  • Lung cancer
  • Lymph node involvement
  • Positron emission tomography
  • SUV
  • Tumor size

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

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