TY - JOUR
T1 - Lymph-Node Ratio in Patients with Cutaneous Melanoma
T2 - A Multi-Institution Prognostic Study
AU - Sandro, Pasquali
AU - Andrea, Maurichi
AU - Nicola, Mozzillo
AU - Simone, Mocellin
AU - Giuseppe, Macripò
AU - Lorenzo, Borgognoni
AU - Nicola, Solari
AU - Dario, Piazzalunga
AU - Luigi, Mascheroni
AU - Giuseppe, Giudice
AU - Roberto, Patuzzo
AU - Corrado, Caracò
AU - Simone, Ribero
AU - Ugo, Marone
AU - Mario, Santinami
AU - Riccardo, Rossi Carlo
PY - 2015/7/8
Y1 - 2015/7/8
N2 - Background: Lymph node ratio (LNR)—the number of metastatic lymph nodes (LNs) over the number of excised LNs after lymphadenectomy—is a prognostic factor for many solid tumors, but controversies still exist for skin melanoma. We investigated the prognostic relevance of LNR in melanoma patients and formulated a proposal for considering the LNR in the current American Joint Committee on Cancer (AJCC) N staging system. Methods: Retrospective data of 2,526 melanoma patients with LN metastasis from nine Italian institutions were collected in a multicenter database. The prognostic value of the LNR (categorized as A, ≤0.1; B, 0.11–0.25; and C, >0.25) was assessed by multivariable survival analysis. Results: LNR was a significant independent prognostic factor for melanoma-specific survival (LNR B vs. A: hazard ratio [HR] 1.47, 95 % CI 1.16–1.87, p = 0.002; LNR C vs. A: HR 1.84, 95 % CI 1.29–2.61, p = 0.001). The LNR had prognostic value in patients with AJCC N1a (one positive LN after sentinel LN biopsy [SLNB], HR 2.33, 95 % CI 1.49–3.63, p
AB - Background: Lymph node ratio (LNR)—the number of metastatic lymph nodes (LNs) over the number of excised LNs after lymphadenectomy—is a prognostic factor for many solid tumors, but controversies still exist for skin melanoma. We investigated the prognostic relevance of LNR in melanoma patients and formulated a proposal for considering the LNR in the current American Joint Committee on Cancer (AJCC) N staging system. Methods: Retrospective data of 2,526 melanoma patients with LN metastasis from nine Italian institutions were collected in a multicenter database. The prognostic value of the LNR (categorized as A, ≤0.1; B, 0.11–0.25; and C, >0.25) was assessed by multivariable survival analysis. Results: LNR was a significant independent prognostic factor for melanoma-specific survival (LNR B vs. A: hazard ratio [HR] 1.47, 95 % CI 1.16–1.87, p = 0.002; LNR C vs. A: HR 1.84, 95 % CI 1.29–2.61, p = 0.001). The LNR had prognostic value in patients with AJCC N1a (one positive LN after sentinel LN biopsy [SLNB], HR 2.33, 95 % CI 1.49–3.63, p
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U2 - 10.1245/s10434-014-4132-5
DO - 10.1245/s10434-014-4132-5
M3 - Article
C2 - 25316489
AN - SCOPUS:84930661349
VL - 22
SP - 2127
EP - 2134
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 7
ER -