Lymphangioleiomyomatosis: What do we know and what are we looking for?

S. Harari, O. Torre, J. Moss

Research output: Contribution to journalArticlepeer-review


Lymphangioleiomyomatosis (LAM) is a rare disease characterised by proliferation of abnormal smooth muscle-like cells (LAM cells) leading to progressive cystic destruction of the lung, lymphatic abnormalities and abdominal tumours. It affects predominantly females and can occur sporadically or in patients with tuberous sclerosis complex. This review describes the recent progress in our understanding of the molecular pathogenesis of the disease and LAM cell biology. It also summarises current therapeutic approaches and the most promising areas of research for future therapeutic strategies.

Original languageEnglish
Pages (from-to)34-44
Number of pages11
JournalEuropean Respiratory Review
Issue number119
Publication statusPublished - Mar 1 2011


  • LAM cells
  • Lymphangioleiomyomatosis
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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