Lymphatic and blood vasculature in primary cutaneous melanomas of the scalp and neck

Sandro Pasquali, Maria Cristina Montesco, Chiara Ginanneschi, Gianna Baroni, Clelia Miracco, Carmelo Urso, Fabio Mele, Anna Rita Lombardi, Pietro Quaglino, Laura Cattaneo, Stefania Staibano, Gerardo Botti, Paolo Visca, Marina Zannoni, Giuseppe Soda, Barbara Corti, Luca Pilloni, Luca Anselmi, Amelia Lissia, Margherita VannucchiCristina Manieli, Daniela Massi

Research output: Contribution to journalArticlepeer-review


Background Scalp/neck melanomas have a poor prognosis, possibly because of a rich vascular supply that prompts tumor cells' dissemination. Methods We compared the accuracy of immunohistochemical (IHC) staining with morphology for the identification of lymphovascular invasion in 156 scalp/neck melanomas. We then analyzed the association of vessel invasion and density with pathological features and survival. Results IHC-detected lymphatic vessel invasion (LVI) and blood vessel invasion (BVI) were identified in 34.6% and 13.5% of cases, respectively. IHC increased the LVI/BVI detection compared to morphology (40.4% vs 16.6%; p

Original languageEnglish
Pages (from-to)1596-1602
Number of pages7
JournalHead and Neck
Issue number11
Publication statusPublished - Nov 1 2015


  • blood vessel density
  • blood vessel invasion
  • cutaneous melanoma
  • head and neck
  • lymphatic vessel density
  • lymphatic vessels invasion
  • scalp and neck

ASJC Scopus subject areas

  • Otorhinolaryngology


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