Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11: International Journal of Cancer

F Ungaro, P Colombo, L Massimino, GS Ugolini, C Correale, M Rasponi, V Garlatti, F Rubbino, C Tacconi, P Spaggiari, A Spinelli, M Carvello, M Sacchi, S Spanò, S Vetrano, A Malesci, L Peyrin-Biroulet, S Danese, S D'Alessio

Research output: Contribution to journalArticle

Abstract

Colorectal cancer (CRC) is one of the most malignant tumors worldwide. Stromal cells residing in the tumor microenvironment strongly contribute to cancer progression through their crosstalk with cancer cells and extracellular matrix. Here we provide the first evidence that CRC-associated lymphatic endothelium displays a distinct matrisome-associated transcriptomic signature, which distinguishes them from healthy intestinal lymphatics. We also demonstrate that CRC-associated human intestinal lymphatic endothelial cells regulate tumor cell growth via growth differentiation factor 11, a soluble matrisome component which in CRC patients was found to be associated with tumor progression. Our data provide new insights into lymphatic contribution to CRC growth, aside from their conventional role as conduits of metastasis. © 2019 UICC
Original languageEnglish
Pages (from-to)1913-1920
Number of pages8
JournalInt. J. Cancer
Volume145
Issue number7
DOIs
Publication statusPublished - 2019

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    Ungaro, F., Colombo, P., Massimino, L., Ugolini, GS., Correale, C., Rasponi, M., Garlatti, V., Rubbino, F., Tacconi, C., Spaggiari, P., Spinelli, A., Carvello, M., Sacchi, M., Spanò, S., Vetrano, S., Malesci, A., Peyrin-Biroulet, L., Danese, S., & D'Alessio, S. (2019). Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11: International Journal of Cancer. Int. J. Cancer, 145(7), 1913-1920. https://doi.org/10.1002/ijc.32286