Lymphnode localization of extramedullary myeloid cell tumor in myelodysplastic syndrome: Report of one case diagnosed by fine-needle cytology

Franco Fulciniti, Pio Zeppa, Gilda Marino, Vincenzo Martinelli, Rosanna Ciancia, Luigi Del Vecchio, Bruno Rotoli, Lucio Palombini

Research output: Contribution to journalArticle

Abstract

Trilineage extramedullary myeloid tumor (EMT) is an uncommon medical condition mostly diagnosed in patients affected by acute or chronic myeloid leukemia or, more rarely, by a myelodysplastic syndrome, among which the most frequent is refractory anemia with excess of blasts in transformation (RAEB-t). The prognostic significance of EMT is still unclear, although the appearance of trilineage EMT is often considered to affect the outcome adversely. A 70-year-old lady with previous history of intestinal resection for colonic adenocarcinoma in 1995 and subsequently treated with 5-fuorouracyl developed a refractory anemia with excess of blasts (RAEB) in 1998. During the follow-up, a progression to RAEB-t was recorded. During chemotherapy for this condition, slight enlargement of left supraclavicular and right submandibular nodes was noticed. Fine-needle biopsy was performed with ancillary studies. A diagnosis of trilineage extramedullary myeloid tumor was reached. The patient was treated with low doses of chemotherapy with a good response lasting 12 months. The peculiar cytologic picture of this condition when corroborated by ancillary studies (immunocytochemistry and flow cytometry) is diagnostic of this rare condition. Furthermore, the extramedullary myeloid tumor in this case did not significantly affect the response to the chemotherapy of RAEB-t.

Original languageEnglish
Pages (from-to)136-139
Number of pages4
JournalDiagnostic Cytopathology
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

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Keywords

  • Fine-needle cytology
  • Hematopathology
  • Myelodysplastic syndromes
  • RAEB-T

ASJC Scopus subject areas

  • Anatomy

Cite this

Fulciniti, F., Zeppa, P., Marino, G., Martinelli, V., Ciancia, R., Del Vecchio, L., Rotoli, B., & Palombini, L. (2003). Lymphnode localization of extramedullary myeloid cell tumor in myelodysplastic syndrome: Report of one case diagnosed by fine-needle cytology. Diagnostic Cytopathology, 28(3), 136-139. https://doi.org/10.1002/dc.10256