Lymphocyte clones from old subjects: growing rate and functional activity

E. Mariani, P. Roda, A. R. Mariani, M. Vitale, A. Degrassi, S. Papa, F. A. Manzoli, A. Facchini

Research output: Contribution to journalArticle

Abstract

Old subjects exhibit a decline in circulating T cells and an impaired proliferative response to mitogens, plus a relative increase in cells with NK phenotype not associated with a concomitant increase in their cytolitic activity. In the present study a limiting dilution assay was used to evaluate the phenotype, the functional activity and the proliferative capacity of clones obtained from peripheral blood lymphocytes of old and young subjects. CD5+ CD8+ clones from old people showed a significant impairment in their proliferative capacity and a decreased lytic activity against K562 and P815-IgG cell lines.

Original languageEnglish
Pages (from-to)103-105
Number of pages3
JournalCytotechnology
Volume1
Issue number1
DOIs
Publication statusPublished - Oct 1987

Keywords

  • aging
  • clone
  • lymphocyte
  • phenotype

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Biotechnology

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  • Cite this

    Mariani, E., Roda, P., Mariani, A. R., Vitale, M., Degrassi, A., Papa, S., Manzoli, F. A., & Facchini, A. (1987). Lymphocyte clones from old subjects: growing rate and functional activity. Cytotechnology, 1(1), 103-105. https://doi.org/10.1007/BF00351134