Lymphocyte membrane receptors in human lymphoid leukemias

M. Ferrarini, G. P. Tonda, A. Risso, G. Viale

Research output: Contribution to journalArticle

Abstract

Membrane bound immunoglobulins, receptors for the Fc fragment of IgG and receptors for the third component of human or murine complement was used as B cell membrane markers to study peripheral blood lymphocytes from 22 patients with chronic lymphatic leukemia (CLL), 5 patients with acute lymphoblastic leukemia (ALL) and one patient with Sezary syndrome. The capacity of human T cells of forming 'spontaneous rosettes' with sheep erythrocytes was employed as T cell membrane marker. In 19 out of 27 CLL or ALL cases tested, a larger percentage of cells than that found in normal individuals expressed at least one of the three B cell membrane markers studied. In the patient with Sezary syndrome the percentage of cells forming 'spontaneous rosettes' with sheep erythrocytes was larger than normal, while the percentage of cells bearing B cells markers was below normal.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalEuropean Journal of Immunology
Volume5
Issue number2
Publication statusPublished - 1975

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Lymphoid Leukemia
Lymphocytes
Sezary Syndrome
B-Lymphocytes
Membranes
Cell Membrane
B-Cell Chronic Lymphocytic Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sheep
Erythrocytes
Immunoglobulin Fc Fragments
T-Lymphocytes
IgG Receptors
B-Cell Antigen Receptors
Fc Receptors

ASJC Scopus subject areas

  • Immunology

Cite this

Ferrarini, M., Tonda, G. P., Risso, A., & Viale, G. (1975). Lymphocyte membrane receptors in human lymphoid leukemias. European Journal of Immunology, 5(2), 89-93.

Lymphocyte membrane receptors in human lymphoid leukemias. / Ferrarini, M.; Tonda, G. P.; Risso, A.; Viale, G.

In: European Journal of Immunology, Vol. 5, No. 2, 1975, p. 89-93.

Research output: Contribution to journalArticle

Ferrarini, M, Tonda, GP, Risso, A & Viale, G 1975, 'Lymphocyte membrane receptors in human lymphoid leukemias', European Journal of Immunology, vol. 5, no. 2, pp. 89-93.
Ferrarini M, Tonda GP, Risso A, Viale G. Lymphocyte membrane receptors in human lymphoid leukemias. European Journal of Immunology. 1975;5(2):89-93.
Ferrarini, M. ; Tonda, G. P. ; Risso, A. ; Viale, G. / Lymphocyte membrane receptors in human lymphoid leukemias. In: European Journal of Immunology. 1975 ; Vol. 5, No. 2. pp. 89-93.
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