Lymphocyte membrane receptors in human lymphoid leukemias

M. Ferrarini, G. P. Tonda, A. Risso, G. Viale

Research output: Contribution to journalArticlepeer-review

Abstract

Membrane bound immunoglobulins, receptors for the Fc fragment of IgG and receptors for the third component of human or murine complement was used as B cell membrane markers to study peripheral blood lymphocytes from 22 patients with chronic lymphatic leukemia (CLL), 5 patients with acute lymphoblastic leukemia (ALL) and one patient with Sezary syndrome. The capacity of human T cells of forming 'spontaneous rosettes' with sheep erythrocytes was employed as T cell membrane marker. In 19 out of 27 CLL or ALL cases tested, a larger percentage of cells than that found in normal individuals expressed at least one of the three B cell membrane markers studied. In the patient with Sezary syndrome the percentage of cells forming 'spontaneous rosettes' with sheep erythrocytes was larger than normal, while the percentage of cells bearing B cells markers was below normal.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalEuropean Journal of Immunology
Volume5
Issue number2
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Immunology

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