Lymphocyte subpopulations in the neonate: Identification of an immature subset of OKT8-positive, OKT3-negative cells

R. Maccario, L. Nespoli, G. Mingrat, A. Vitiello, A. G. Ugazio, G. R. Burgio

Research output: Contribution to journalArticle

Abstract

T cell subpopulations of lymphocytes from cord blood (CBL) of 24 newborns and from peripheral blood (a-PBL) of 24 healthy adult volunteers were assessed in T cell-enriched, T cell depleted and unseparated lymphocyte fractions by using OKT3, 4, 6, and 8 monoclonal antibodies. The results show that T cell-enriched CBL include adult numbers of OKT3 +, OKT4 +, OKT6 + and OKT8 + lymphocytes whereas the T cell-depleted fraction consists of a high percentage of OKT8 +, OKT3 -, non-E rosette-forming cells bearing a PNA receptor. The presence of the PNA receptor and the lack of the OKT3 + antigen strongly support the hypothesis that the subset of OKT8 + cells in cord blood includes immature T lymphocytes that may represent an intermediate stage between thymocytes and mature peripheral T cells.

Original languageEnglish
Pages (from-to)1129-1131
Number of pages3
JournalJournal of Immunology
Volume130
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Immunology

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