TY - JOUR
T1 - Lymphocyte subpopulations in the neonate
T2 - Identification of an immature subset of OKT8-positive, OKT3-negative cells
AU - Maccario, R.
AU - Nespoli, L.
AU - Mingrat, G.
AU - Vitiello, A.
AU - Ugazio, A. G.
AU - Burgio, G. R.
PY - 1983
Y1 - 1983
N2 - T cell subpopulations of lymphocytes from cord blood (CBL) of 24 newborns and from peripheral blood (a-PBL) of 24 healthy adult volunteers were assessed in T cell-enriched, T cell depleted and unseparated lymphocyte fractions by using OKT3, 4, 6, and 8 monoclonal antibodies. The results show that T cell-enriched CBL include adult numbers of OKT3 +, OKT4 +, OKT6 + and OKT8 + lymphocytes whereas the T cell-depleted fraction consists of a high percentage of OKT8 +, OKT3 -, non-E rosette-forming cells bearing a PNA receptor. The presence of the PNA receptor and the lack of the OKT3 + antigen strongly support the hypothesis that the subset of OKT8 + cells in cord blood includes immature T lymphocytes that may represent an intermediate stage between thymocytes and mature peripheral T cells.
AB - T cell subpopulations of lymphocytes from cord blood (CBL) of 24 newborns and from peripheral blood (a-PBL) of 24 healthy adult volunteers were assessed in T cell-enriched, T cell depleted and unseparated lymphocyte fractions by using OKT3, 4, 6, and 8 monoclonal antibodies. The results show that T cell-enriched CBL include adult numbers of OKT3 +, OKT4 +, OKT6 + and OKT8 + lymphocytes whereas the T cell-depleted fraction consists of a high percentage of OKT8 +, OKT3 -, non-E rosette-forming cells bearing a PNA receptor. The presence of the PNA receptor and the lack of the OKT3 + antigen strongly support the hypothesis that the subset of OKT8 + cells in cord blood includes immature T lymphocytes that may represent an intermediate stage between thymocytes and mature peripheral T cells.
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M3 - Article
C2 - 6600473
AN - SCOPUS:0020658977
VL - 130
SP - 1129
EP - 1131
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 3
ER -