In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.
|Translated title of the contribution||Lymphocyte subpopulations present circadian variation of some of their subsets and this variation may influence magnitude and expression of the immune responses|
|Number of pages||4|
|Journal||Recenti Progressi in Medicina|
|Publication status||Published - Nov 1998|
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