Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani

Translated title of the contribution: Lymphocyte subpopulations present circadian variation of some of their subsets and this variation may influence magnitude and expression of the immune responses

Gianluigi Mazzoccoli, Giovanni Bianco, Massimo Correra, Angelo Michele Carella, Mario Balzanelli, Antonio Giuliani, Roberto Tarquini

Research output: Contribution to journalArticlepeer-review

Abstract

In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.

Translated title of the contributionLymphocyte subpopulations present circadian variation of some of their subsets and this variation may influence magnitude and expression of the immune responses
Original languageItalian
Pages (from-to)569-572
Number of pages4
JournalRecenti Progressi in Medicina
Volume89
Issue number11
Publication statusPublished - Nov 1998

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Lymphocyte subpopulations present circadian variation of some of their subsets and this variation may influence magnitude and expression of the immune responses'. Together they form a unique fingerprint.

Cite this