Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani

Gianluigi Mazzoccoli; Giovanni Bianco; Massimo Correra; Angelo Michele Carella; Mario Balzanelli; Antonio Giuliani; Roberto Tarquini

Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani

Translated title of the contribution: Lymphocyte subpopulations present circadian variation of some of their subsets and this variation may influence magnitude and expression of the immune responses

Gianluigi Mazzoccoli, Giovanni Bianco, Massimo Correra, Angelo Michele Carella, Mario Balzanelli, Antonio Giuliani, Roberto Tarquini

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8^dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 ^bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.

Translated title of the contribution	Lymphocyte subpopulations present circadian variation of some of their subsets and this variation may influence magnitude and expression of the immune responses
Original language	Italian
Pages (from-to)	569-572
Number of pages	4
Journal	Recenti Progressi in Medicina
Volume	89
Issue number	11
Publication status	Published - Nov 1998

ASJC Scopus subject areas

Medicine(all)

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title = "Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani",

abstract = "In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.",

keywords = "Circadian rhythm, Immune response, Interleukin 2, Lymphocyte subpopulations",

author = "Gianluigi Mazzoccoli and Giovanni Bianco and Massimo Correra and Carella, {Angelo Michele} and Mario Balzanelli and Antonio Giuliani and Roberto Tarquini",

year = "1998",

month = nov,

language = "Italian",

volume = "89",

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journal = "Recenti Progressi in Medicina",

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T1 - Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani

AU - Mazzoccoli, Gianluigi

AU - Bianco, Giovanni

AU - Correra, Massimo

AU - Carella, Angelo Michele

AU - Balzanelli, Mario

AU - Giuliani, Antonio

AU - Tarquini, Roberto

PY - 1998/11

Y1 - 1998/11

N2 - In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.

AB - In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.

KW - Circadian rhythm

KW - Immune response

KW - Interleukin 2

KW - Lymphocyte subpopulations

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