Abstract
In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.
| Original language | Italian |
|---|---|
| Pages (from-to) | 569-572 |
| Number of pages | 4 |
| Journal | Recenti Progressi in Medicina |
| Volume | 89 |
| Issue number | 11 |
| Publication status | Published - Nov 1998 |
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ASJC Scopus subject areas
- Medicine(all)
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Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani. / Mazzoccoli, Gianluigi; Bianco, Giovanni; Correra, Massimo; Carella, Angelo Michele; Balzanelli, Mario; Giuliani, Antonio; Tarquini, Roberto.
In: Recenti Progressi in Medicina, Vol. 89, No. 11, 11.1998, p. 569-572.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ritmo circadiano delle sottopopolazioni linfocitarie in soggetti sani
AU - Mazzoccoli, Gianluigi
AU - Bianco, Giovanni
AU - Correra, Massimo
AU - Carella, Angelo Michele
AU - Balzanelli, Mario
AU - Giuliani, Antonio
AU - Tarquini, Roberto
PY - 1998/11
Y1 - 1998/11
N2 - In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.
AB - In our study cortisol and interleukin 2 (IL-2) levels were measured and lymphocyte subpopulation analyses were performed on blood samples collected every four hours, for 24 hours from 10 healthy subjects aged 38-65 years. A clear circadian rhythm was validated for cortisol serum levels, for CD8, CD8dim, CD16 and δTcS1 with acrophase in the morning, and for CD2, CD4, CD4/CD8 ratio, HLA-DR, CD20 and CD25 with acrophase at night. CD8 bright and TcRδ1 presented higher levels in the morning without validation of the circadian rhythm. Changes of serum levels of IL-2 did not show circadian rhythmicity. The results show that specific lymphocyte subsets present different profiles of nyctohemeral changes and this may explain time related variations of immune responses.
KW - Circadian rhythm
KW - Immune response
KW - Interleukin 2
KW - Lymphocyte subpopulations
UR - http://www.scopus.com/inward/record.url?scp=0032200633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032200633&partnerID=8YFLogxK
M3 - Articolo
C2 - 9844441
AN - SCOPUS:0032200633
VL - 89
SP - 569
EP - 572
JO - Recenti Progressi in Medicina
JF - Recenti Progressi in Medicina
SN - 0034-1193
IS - 11
ER -