Valori di riferimento delle principali sottopopolazioni linfocitarie. Risultati di uno studio policentrico su soggetti adulti

Translated title of the contribution: Lymphocyte subset reference ranges. Results of a multicenter clinical trial on healthy adults

A. Santagostino, G. Garbaccio, M. Girotto, A. Pistorio, C. Rabascio, V. Bolis

Research output: Contribution to journalArticle


This paper presents the results of a multicenter clinical trial which defines the reference range, in terms of percent and absolute count, for lymphocyte subset in healthy adults. We studied the distribution of lymphocyte subsets CD3+, CD3+CD4+, CD3+CD8+, CD3+DR+, CD19+, DR+, CD16+ and/or CD56+CD3- in 419 Italian healthy adults, most of them were periodic blood donors. In order to standardize the pre-analytical and analytical phases some recommendation was given to each laboratory; so, we obtained an high degree of concordance between observations at each site. Another aim of this study was to reveal differences in lymphocyte subset due to some variables like sex, age and smoke. Finally, we compared the data of leucocyte formula obtained by the haematological counters and by cytometer.

Original languageItalian
Pages (from-to)337-344
Number of pages8
JournalTrasfusione del Sangue
Issue number6
Publication statusPublished - 1998


ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

Cite this