Lymphocyte subsets are influenced by positivity levels in healthy subjects before and after mild acute stress

Gian Vittorio Caprara, Roberto Nisini, Valeria Castellani, Vittorio Pasquali, Guido Alessandri, Ziparo Vincenzo, Ferlito Claudia, Germano Valentina, Andrea Picchianti Diamanti, Michela Ileen Biondo, Francesca Milanetti, Gerardo Salerno, Visco Vincenzo, Pietrosanti Mario, Eros Aniballi, Salemi Simonetta, Santoni Angela, Raffaele D'Amelio

Research output: Contribution to journalArticle

Abstract

In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acute stress test, in 41 healthy students, previously selected by a questionnaire for their level of POS (high [POS-H] and low [POS-L]). The CD3+ and CD4+ cell frequency was higher in the POS-H students before and after acute stress. CD4+ subpopulation analysis revealed baseline higher terminally differentiated frequency in the POS-H, whereas higher effector memory frequency was present in the POS-L students. Moreover, the frequency of post-stress B cells was higher in the POS-H students. The mild-stress test was associated to an increase of the IL-10 mean values, while mean values of the other cytokines tested did not change significantly. It is tempting to speculate that IL-10 may work as biomarker of response to acute mild stress and that POS-H may be associated to a better capacity of the immune system to contrast the disturbing effects of mild acute stress. Yet further studies on lymphocyte subset absolute number and function of larger and different populations are needed to definitively prove these preliminary observations.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalImmunology Letters
Volume188
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • Lymphocyte subsets
  • Positivity
  • Stress

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Caprara, G. V., Nisini, R., Castellani, V., Pasquali, V., Alessandri, G., Vincenzo, Z., Claudia, F., Valentina, G., Picchianti Diamanti, A., Biondo, M. I., Milanetti, F., Salerno, G., Vincenzo, V., Mario, P., Aniballi, E., Simonetta, S., Angela, S., & D'Amelio, R. (2017). Lymphocyte subsets are influenced by positivity levels in healthy subjects before and after mild acute stress. Immunology Letters, 188, 13-20. https://doi.org/10.1016/j.imlet.2017.05.012