Lymphocyte subsets in idiopathic thrombocytopenic purpura: Relationship with disease activity and therapy

A. Della Volpe, L. Baldini, A. Neri

Research output: Contribution to journalArticle

Abstract

Peripheral lymphocyte subsets of 39 adult idiopathic thrombocytopenic purpura (ITP) at various clinical phases were evaluated by means of several immunological techniques (SmIg, E rosettes, and monoclonal antibodies OKT3, OKT4 and OKT8). The patients were grouped for statistical analysis according to platelet count, disease phase, and response to therapies. The only observed alteration in the absolute numbers was the reduction of SmIg + and OKT3 + cells in the prednisone responders versus the splenectomy responders. We found a significant reduction in the percentage of OKT4 + cells both in the 'responder' group as a whole and in those patients cured by splenectomy, but no significant differences were noted between any of the groups in the T4/T8 ratio. We did not find any significant alteration in the untreated ITP patients. Our results seem therefore to indicate aspecific alterations, perhaps induced by therapies, rather than a specific imbalance of circulating lymphocyte subsets in ITP patients.

Original languageEnglish
Pages (from-to)733-739
Number of pages7
JournalCurrent Therapeutic Research
Volume36
Issue number4
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Medicine(all)

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