Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables

Cinzia Masserini, Antonio Vita, Roberto Basile, Raffaele Morselli, Paolo Boato, Cinzia Peruzzi, Luigi Pugnetti, Pasquale Ferrante, Carlo Lorenzo Cazzullo

Research output: Contribution to journalArticle

Abstract

Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalSchizophrenia Research
Volume3
Issue number4
DOIs
Publication statusPublished - 1990

Fingerprint

Lymphocyte Subsets
Schizophrenia
Pharmaceutical Preparations
Antipsychotic Agents
Healthy Volunteers
Therapeutics
Lymphocytes
Lymphocyte Count
Helper-Inducer T-Lymphocytes
Diagnostic and Statistical Manual of Mental Disorders
Immunoglobulins
B-Lymphocytes
Serum

Keywords

  • Immunoglobubin
  • Lymphocyte subset
  • Neuroleptic side effect
  • Schizophrenic disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Masserini, C., Vita, A., Basile, R., Morselli, R., Boato, P., Peruzzi, C., ... Cazzullo, C. L. (1990). Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables. Schizophrenia Research, 3(4), 269-275. https://doi.org/10.1016/0920-9964(90)90008-U

Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables. / Masserini, Cinzia; Vita, Antonio; Basile, Roberto; Morselli, Raffaele; Boato, Paolo; Peruzzi, Cinzia; Pugnetti, Luigi; Ferrante, Pasquale; Cazzullo, Carlo Lorenzo.

In: Schizophrenia Research, Vol. 3, No. 4, 1990, p. 269-275.

Research output: Contribution to journalArticle

Masserini, C, Vita, A, Basile, R, Morselli, R, Boato, P, Peruzzi, C, Pugnetti, L, Ferrante, P & Cazzullo, CL 1990, 'Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables', Schizophrenia Research, vol. 3, no. 4, pp. 269-275. https://doi.org/10.1016/0920-9964(90)90008-U
Masserini, Cinzia ; Vita, Antonio ; Basile, Roberto ; Morselli, Raffaele ; Boato, Paolo ; Peruzzi, Cinzia ; Pugnetti, Luigi ; Ferrante, Pasquale ; Cazzullo, Carlo Lorenzo. / Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables. In: Schizophrenia Research. 1990 ; Vol. 3, No. 4. pp. 269-275.
@article{3e39e7b453aa4e328f78e2f7386d1fe1,
title = "Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables",
abstract = "Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.",
keywords = "Immunoglobubin, Lymphocyte subset, Neuroleptic side effect, Schizophrenic disorder",
author = "Cinzia Masserini and Antonio Vita and Roberto Basile and Raffaele Morselli and Paolo Boato and Cinzia Peruzzi and Luigi Pugnetti and Pasquale Ferrante and Cazzullo, {Carlo Lorenzo}",
year = "1990",
doi = "10.1016/0920-9964(90)90008-U",
language = "English",
volume = "3",
pages = "269--275",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier B.V.",
number = "4",

}

TY - JOUR

T1 - Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables

AU - Masserini, Cinzia

AU - Vita, Antonio

AU - Basile, Roberto

AU - Morselli, Raffaele

AU - Boato, Paolo

AU - Peruzzi, Cinzia

AU - Pugnetti, Luigi

AU - Ferrante, Pasquale

AU - Cazzullo, Carlo Lorenzo

PY - 1990

Y1 - 1990

N2 - Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.

AB - Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.

KW - Immunoglobubin

KW - Lymphocyte subset

KW - Neuroleptic side effect

KW - Schizophrenic disorder

UR - http://www.scopus.com/inward/record.url?scp=0025351623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025351623&partnerID=8YFLogxK

U2 - 10.1016/0920-9964(90)90008-U

DO - 10.1016/0920-9964(90)90008-U

M3 - Article

C2 - 1980614

AN - SCOPUS:0025351623

VL - 3

SP - 269

EP - 275

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 4

ER -