Abstract
Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.
| Original language | English |
|---|---|
| Pages (from-to) | 269-275 |
| Number of pages | 7 |
| Journal | Schizophrenia Research |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1990 |
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Keywords
- Immunoglobubin
- Lymphocyte subset
- Neuroleptic side effect
- Schizophrenic disorder
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables. / Masserini, Cinzia; Vita, Antonio; Basile, Roberto; Morselli, Raffaele; Boato, Paolo; Peruzzi, Cinzia; Pugnetti, Luigi; Ferrante, Pasquale; Cazzullo, Carlo Lorenzo.
In: Schizophrenia Research, Vol. 3, No. 4, 1990, p. 269-275.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphocyte subsets in schizophrenic disorders. relationship with clinical, neuromorphological and treatment variables
AU - Masserini, Cinzia
AU - Vita, Antonio
AU - Basile, Roberto
AU - Morselli, Raffaele
AU - Boato, Paolo
AU - Peruzzi, Cinzia
AU - Pugnetti, Luigi
AU - Ferrante, Pasquale
AU - Cazzullo, Carlo Lorenzo
PY - 1990
Y1 - 1990
N2 - Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.
AB - Peripheral blood lymphocyte subsets and serum immunoglobulin levels were assessed in 42 patients and 37 healthy controls. 24 patients were free from neuroleptic medication and 15 had never been treated with neuroleptics. 31 patients had a diagnosis of schizophrenia (DSM-III criteria) and 11 a diagnosis of a disorder of the schizophrenic spectrum. As compared to healthy subjects, the drug naive schizophrenic patient group showed an increase of T suppressor lymphocytes, while the drug-treated schizophrenic group showed an increase of T helper lymphocytes. The drug-treated schizophrenic group differed from the drug naive one relative to a decrease of T suppressor lymphocytes. As compared to healthy subjects, the drug naive spectrum disorder patients showed an increase of absolute number of lymphocytes, while the drug treated spectrum group showed an increase of B lymphocytes. These findings did not correlate with any clinical or neuromorphological variables taken into account.
KW - Immunoglobubin
KW - Lymphocyte subset
KW - Neuroleptic side effect
KW - Schizophrenic disorder
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U2 - 10.1016/0920-9964(90)90008-U
DO - 10.1016/0920-9964(90)90008-U
M3 - Article
C2 - 1980614
AN - SCOPUS:0025351623
VL - 3
SP - 269
EP - 275
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 4
ER -