Abstract
Between July 1970 and April 1972, peripheral lymphocytes of 35 patients with malignant melanoma were tested for in vitro cytotoxicity to autologous or homologous melanoma cells. Twenty-one cases (60%) had lymphocytes with a specific cytotoxic activity. No correlation was found with sex, age or clinical stage of the disease. To evaluate the prognostic significance of the in vitro cytotoxic activity of peripheral lymphocytes, 18 patients at stage I and II, who had been subjected to radical surgery prior to the cytotoxic test, were divided into two groups according to the result of the test (12 positives and 6 negatives) and were followed up for a maximum period of 32 months. Twelve cases had recurrence of the disease: 7 of the 12 cases with positive lymphocytes, and five of the 6 patients with negative lymphocytes. The difference between the two groups was not significant. The tumour-free interval has been 8·4 months in the seven cases with cytotoxic lymphocytes and 8 months in the 5 cases with no reactive ones.
| Original language | English |
|---|---|
| Pages (from-to) | 843-846 |
| Number of pages | 4 |
| Journal | European Journal of Cancer (1965) |
| Volume | 9 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - 1973 |
Fingerprint
ASJC Scopus subject areas
- Oncology
Cite this
Lymphocyte toxicity test in clinical melanoma. / Veronesi, Umberto; Cascinelli, Natale; Fossati, Giuseppe; Canevari, Silvana; Balzarini, Gianpaolo.
In: European Journal of Cancer (1965), Vol. 9, No. 11-12, 1973, p. 843-846.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lymphocyte toxicity test in clinical melanoma
AU - Veronesi, Umberto
AU - Cascinelli, Natale
AU - Fossati, Giuseppe
AU - Canevari, Silvana
AU - Balzarini, Gianpaolo
PY - 1973
Y1 - 1973
N2 - Between July 1970 and April 1972, peripheral lymphocytes of 35 patients with malignant melanoma were tested for in vitro cytotoxicity to autologous or homologous melanoma cells. Twenty-one cases (60%) had lymphocytes with a specific cytotoxic activity. No correlation was found with sex, age or clinical stage of the disease. To evaluate the prognostic significance of the in vitro cytotoxic activity of peripheral lymphocytes, 18 patients at stage I and II, who had been subjected to radical surgery prior to the cytotoxic test, were divided into two groups according to the result of the test (12 positives and 6 negatives) and were followed up for a maximum period of 32 months. Twelve cases had recurrence of the disease: 7 of the 12 cases with positive lymphocytes, and five of the 6 patients with negative lymphocytes. The difference between the two groups was not significant. The tumour-free interval has been 8·4 months in the seven cases with cytotoxic lymphocytes and 8 months in the 5 cases with no reactive ones.
AB - Between July 1970 and April 1972, peripheral lymphocytes of 35 patients with malignant melanoma were tested for in vitro cytotoxicity to autologous or homologous melanoma cells. Twenty-one cases (60%) had lymphocytes with a specific cytotoxic activity. No correlation was found with sex, age or clinical stage of the disease. To evaluate the prognostic significance of the in vitro cytotoxic activity of peripheral lymphocytes, 18 patients at stage I and II, who had been subjected to radical surgery prior to the cytotoxic test, were divided into two groups according to the result of the test (12 positives and 6 negatives) and were followed up for a maximum period of 32 months. Twelve cases had recurrence of the disease: 7 of the 12 cases with positive lymphocytes, and five of the 6 patients with negative lymphocytes. The difference between the two groups was not significant. The tumour-free interval has been 8·4 months in the seven cases with cytotoxic lymphocytes and 8 months in the 5 cases with no reactive ones.
UR - http://www.scopus.com/inward/record.url?scp=0015705476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015705476&partnerID=8YFLogxK
U2 - 10.1016/0014-2964(73)90025-X
DO - 10.1016/0014-2964(73)90025-X
M3 - Article
C2 - 4804311
AN - SCOPUS:0015705476
VL - 9
SP - 843
EP - 846
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0014-2964
IS - 11-12
ER -