Lymphocytes subpopulations and natural killer activity in familiar idiopathic hypoparathyroidism

P. De Paoli, S. Battistin, M. G. Del Ben

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Two families with idiopathic hypoparathyroidism are described. All of the eight patients do not suffer of cutaneous mucocandidiasis or other endocrinopathies; the disease is transmitted as an autosomal dominant trait and is not HLA associated; imbalances in lymphocytes subpopulations, studied with monoclonal antibodies and flow cytometry, were found. Leu 7+ cells and natural killer activity are both increased. OKT 3+ cells appear to be reduced without alterations of the T4/T8 ratio. Anti thyroid and anti surrenal antibodies have been found in the sera of some of our patients. The results obtained are discussed and special attention is given to the possible relationships between endocrine glands function and cell mediated immunity.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalImmunologia Clinica e Sperimentale
Issue number3
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Immunology and Allergy


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