Lymphocytes subpopulations and natural killer activity in familiar idiopathic hypoparathyroidism

P. De Paoli, S. Battistin, M. G. Del Ben

Research output: Contribution to journalArticle

Abstract

Two families with idiopathic hypoparathyroidism are described. All of the eight patients do not suffer of cutaneous mucocandidiasis or other endocrinopathies; the disease is transmitted as an autosomal dominant trait and is not HLA associated; imbalances in lymphocytes subpopulations, studied with monoclonal antibodies and flow cytometry, were found. Leu 7+ cells and natural killer activity are both increased. OKT 3+ cells appear to be reduced without alterations of the T4/T8 ratio. Anti thyroid and anti surrenal antibodies have been found in the sera of some of our patients. The results obtained are discussed and special attention is given to the possible relationships between endocrine glands function and cell mediated immunity.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalImmunologia Clinica e Sperimentale
Volume3
Issue number3
Publication statusPublished - 1984

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Hypoparathyroidism
Lymphocyte Subsets
Endocrine Glands
CD4-CD8 Ratio
Endocrine Cells
Cellular Immunity
Natural Killer Cells
Anti-Idiotypic Antibodies
Flow Cytometry
Thyroid Gland
Monoclonal Antibodies
Skin
Serum

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Lymphocytes subpopulations and natural killer activity in familiar idiopathic hypoparathyroidism. / De Paoli, P.; Battistin, S.; Del Ben, M. G.

In: Immunologia Clinica e Sperimentale, Vol. 3, No. 3, 1984, p. 185-191.

Research output: Contribution to journalArticle

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