Lymphocytic gastritis: A positive relationship with celiac disease

C. De Giacomo, A. Gianatti, R. Negrini, P. Perotti, P. Bawa, G. Maggiore, R. Fiocca

Research output: Contribution to journalArticle

Abstract

Lymphocytic gastritis is characterized by lymphocytic infiltration of the surface and pit epithelium. Its cause has not been established, but an association with Helicobacter pylori infection or celiac disease has been suggested. We evaluated the histologic featues of both gastric and duodenal biopsy specimens from 245 consecutive children and adolescents, and found chronic gastritis in 60 children and celiac disease in 25. Chronic gastritis was associated with H. pylori infection in 36 children and with celiac diseases in 15. Lymphocytic gastritis was found in nine children with celiac disease. Children with lymphocytic gastritis had a mean of 40.64 lymphocytes per 100 epithelial cells, compared with a mean of 3.92 lymphocytes per 100 epithelial cells in children with H. pylori-associated gastritis and 5.15 lymphocytes in normal control subjects. Immunohistochemical studies showed that the intraepithelial lymphocytes in lymphocytic gastritis were T cells. No child with lymphocytic gastritis had serologic evidence of past H. pylori infection. We conclude that lymphocytic gastritis in children is associated with celiac disease. Dyspeptic symptoms are frequent; the endoscopic appearance is not characteristic.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalJournal of Pediatrics
Volume124
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    De Giacomo, C., Gianatti, A., Negrini, R., Perotti, P., Bawa, P., Maggiore, G., & Fiocca, R. (1994). Lymphocytic gastritis: A positive relationship with celiac disease. Journal of Pediatrics, 124(1), 57-62.