Lymphocytotoxicity against autologous hepatocytes and membrane-bound IgG in viral and autoimmune chronic active hepatitis

G. F. Stefanini, R. Meliconi, F. Miglio, M. Mazzetti, M. Baraldini, A. Facchini, G. Gasbarrini

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Abstract

Membrane-bound IgG and lymphocytotoxic activity of total, T-enriched and T-depleted lymphocytes, using autologous hepatocytes have been evaluated in: (a) 31 patients with chronic active hepatitis (CAH)(six autoimmune and 25 hepatitis B virus - HBV-related); (b) five patients with inactive alcoholic cirrhosis; and (c) nine subjects with normal hepatic histology. Lymphocytotoxicity was positive in 83% of autoimmune CAH and 68% of HBV-related cases; it was confined to the T-depleted subpopulation in the first group, while it was present in both the T-enriched and T-depleted subpopulations in 81% of HBV-related cases. Membrane-bound IgG was present in 58% of group (a) and in none of the other groups. A linear pattern was found in four out of five autoimmune CAH patients with positive lymphocytotoxic activity. The autoimmune patient with lymphocytotoxic activity within the normal range did not show any membrane fluorescence. Among HBV-related CAH patients, 13 presented a granular pattern, two an associated granular and linear pattern and ten were negative. These data suggest that different lymphocytotoxic mechanisms are involved in the two forms of CAH studied.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalLiver
Volume3
Issue number1
Publication statusPublished - 1983

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Autoimmune Hepatitis
Chronic Hepatitis
Hepatocytes
Immunoglobulin G
Membranes
Alcoholic Liver Cirrhosis
Hepatitis B virus
Histology
Reference Values
Fluorescence
Lymphocytes
Liver

ASJC Scopus subject areas

  • Hepatology

Cite this

Stefanini, G. F., Meliconi, R., Miglio, F., Mazzetti, M., Baraldini, M., Facchini, A., & Gasbarrini, G. (1983). Lymphocytotoxicity against autologous hepatocytes and membrane-bound IgG in viral and autoimmune chronic active hepatitis. Liver, 3(1), 36-45.

Lymphocytotoxicity against autologous hepatocytes and membrane-bound IgG in viral and autoimmune chronic active hepatitis. / Stefanini, G. F.; Meliconi, R.; Miglio, F.; Mazzetti, M.; Baraldini, M.; Facchini, A.; Gasbarrini, G.

In: Liver, Vol. 3, No. 1, 1983, p. 36-45.

Research output: Contribution to journalArticle

Stefanini, GF, Meliconi, R, Miglio, F, Mazzetti, M, Baraldini, M, Facchini, A & Gasbarrini, G 1983, 'Lymphocytotoxicity against autologous hepatocytes and membrane-bound IgG in viral and autoimmune chronic active hepatitis', Liver, vol. 3, no. 1, pp. 36-45.
Stefanini, G. F. ; Meliconi, R. ; Miglio, F. ; Mazzetti, M. ; Baraldini, M. ; Facchini, A. ; Gasbarrini, G. / Lymphocytotoxicity against autologous hepatocytes and membrane-bound IgG in viral and autoimmune chronic active hepatitis. In: Liver. 1983 ; Vol. 3, No. 1. pp. 36-45.
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AU - Stefanini, G. F.

AU - Meliconi, R.

AU - Miglio, F.

AU - Mazzetti, M.

AU - Baraldini, M.

AU - Facchini, A.

AU - Gasbarrini, G.

PY - 1983

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N2 - Membrane-bound IgG and lymphocytotoxic activity of total, T-enriched and T-depleted lymphocytes, using autologous hepatocytes have been evaluated in: (a) 31 patients with chronic active hepatitis (CAH)(six autoimmune and 25 hepatitis B virus - HBV-related); (b) five patients with inactive alcoholic cirrhosis; and (c) nine subjects with normal hepatic histology. Lymphocytotoxicity was positive in 83% of autoimmune CAH and 68% of HBV-related cases; it was confined to the T-depleted subpopulation in the first group, while it was present in both the T-enriched and T-depleted subpopulations in 81% of HBV-related cases. Membrane-bound IgG was present in 58% of group (a) and in none of the other groups. A linear pattern was found in four out of five autoimmune CAH patients with positive lymphocytotoxic activity. The autoimmune patient with lymphocytotoxic activity within the normal range did not show any membrane fluorescence. Among HBV-related CAH patients, 13 presented a granular pattern, two an associated granular and linear pattern and ten were negative. These data suggest that different lymphocytotoxic mechanisms are involved in the two forms of CAH studied.

AB - Membrane-bound IgG and lymphocytotoxic activity of total, T-enriched and T-depleted lymphocytes, using autologous hepatocytes have been evaluated in: (a) 31 patients with chronic active hepatitis (CAH)(six autoimmune and 25 hepatitis B virus - HBV-related); (b) five patients with inactive alcoholic cirrhosis; and (c) nine subjects with normal hepatic histology. Lymphocytotoxicity was positive in 83% of autoimmune CAH and 68% of HBV-related cases; it was confined to the T-depleted subpopulation in the first group, while it was present in both the T-enriched and T-depleted subpopulations in 81% of HBV-related cases. Membrane-bound IgG was present in 58% of group (a) and in none of the other groups. A linear pattern was found in four out of five autoimmune CAH patients with positive lymphocytotoxic activity. The autoimmune patient with lymphocytotoxic activity within the normal range did not show any membrane fluorescence. Among HBV-related CAH patients, 13 presented a granular pattern, two an associated granular and linear pattern and ten were negative. These data suggest that different lymphocytotoxic mechanisms are involved in the two forms of CAH studied.

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